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Synthesis and Biological Activity of Pyrazolo[1,5-c][1,3]benzoxazines Containing a Thiazolidin-4-one Fragment

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Abstract

5-[4-(2-Aryl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazin-5-yl)benzylidene]-1,3-thiazolidin-4-ones were synthesized by reactions of 4-[(3-R-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzaldehydes with 2-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)phenols and evaluated for antitumor and anti-inflammatory activities.

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Authors and Affiliations

  1. Danylo Halitsky Lviv National Medical University, 79010, Lviv, Ukraine

    V. Y. Horishny

  2. Ivano-Frankivsk National Medical University, 76018, Ivano-Frankivsk, Ukraine

    L. Z. Mandzyuk & O. V. Bodnarchuk

  3. Ivan Franko National University of Lviv, 79005, Lviv, Ukraine

    R. Z. Lytvyn, V. S. Matiychuk & M. D. Obushak

Authors
  1. V. Y. Horishny
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  2. L. Z. Mandzyuk
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  3. R. Z. Lytvyn
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  4. O. V. Bodnarchuk
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  5. V. S. Matiychuk
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  6. M. D. Obushak
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Corresponding author

Correspondence to M. D. Obushak.

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Horishny, V.Y., Mandzyuk, L.Z., Lytvyn, R.Z. et al. Synthesis and Biological Activity of Pyrazolo[1,5-c][1,3]benzoxazines Containing a Thiazolidin-4-one Fragment. Russ J Org Chem 56, 588–595 (2020). https://doi.org/10.1134/S1070428020040053

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  • DOI: https://doi.org/10.1134/S1070428020040053

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