Skip to main content
Log in

Evaluation of Applicability of Aminodiphosphonic Acids for the Development of Bone-Seeking 68Ga-Radiopharmaceuticals

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

The binding of 68Ga to two organic ligands containing aminodiphosphonic groups (1,7-diamino-4-oxaheptane-1,1,7,7-tetraphosphonic and 1,7-diamino-4-hydroxycarbonylheptane-1,1,7,7-tetraphosphonic acids) has been examined. The stability and osteotropic potential of the labeled compounds have been evaluated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme
Scheme
Fig. 1.

Similar content being viewed by others

REFERENCES

  1. Roodman, G.D., N. Engl. J. Med., 2004, vol. 350, no. 16, p. 1655. https://doi.org/10.1056/NEJMra030831

    Article  CAS  PubMed  Google Scholar 

  2. Weilbaecher, K.N., Guise, T.A., and McCauley, L.K., Nat. Rev. Cancer, 2011, vol. 11, no. 6, p. 411. https://doi.org/10.1038/nrc3055

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Zheng, Y., Zhou, H., Dunstan, C.R., Sutherland, R.L., and Seibel, M.J., J. Bone Oncol., 2013, vol. 2, no. 1, p. 47. https://doi.org/10.1016/J.JBO.2012.11.002

    Article  PubMed  Google Scholar 

  4. Kodina, G.E., Malysheva, A.O., and Klement’eva, O.E., Russ. Chem. Bull., 2016, vol. 65, no. 2, p. 350. https://doi.org/10.1007/s11172-016-1308-0

    Article  CAS  Google Scholar 

  5. Russell, R.G.G., Bone, 2011, vol. 49, no. 1, p. 2. https://doi.org/10.1016/j.bone.2011.04.022

    Article  CAS  PubMed  Google Scholar 

  6. Fleisch, H., Russell, R.G.G., Bisaz, S., Casey, P.A., and Mühlbauer, R.C., Calcif. Tissue Res., 1968, vol. 2, no. 1, p. 10. https://doi.org/10.1007/BF02065192

    Article  Google Scholar 

  7. Kochmant, M., Rutter, W.J., Horecker, B.L., Nat, P., Sci, A., and Two, A., Science, 1969, vol. 165, no. 3899, p. 1262. https://doi.org/10.1126/science.165.3899.1262

    Article  Google Scholar 

  8. Russell, R.G.G., Watts, N.B., EbetiN, F.H., and Rogers, M.J., Osteoporos. Int., 2008, vol. 19, no. 6, p. 733. https://doi.org/10.1007/s00198-007-0540-8

    Article  CAS  PubMed  Google Scholar 

  9. Larenkov, A.A., Kodina, G.E., and Bruskin, A.B., Med. Radiolog. Radiatsion. Bezopasnost’, 2011, vol. 56, no. 5, p. 56.

    Google Scholar 

  10. Roesch, F.J. and Riss, P., Curr. Top. Med. Chem., 2012, vol. 10, no. 16, p. 1633. https://doi.org/10.2174/156802610793176738

    Article  Google Scholar 

  11. Velikyan, I., Theranostics., 2014, vol. 4, no. 1, p. 47. https://doi.org/10.7150/thno.7447

    Article  CAS  Google Scholar 

  12. Wu, Z., Zha, Z., Choi, S.R., Plössl, K., Zhu, L., and Kung, H.F., Nucl. Med. Biol., 2016, vol. 43, no. 6, p. 360. https://doi.org/10.1016/j.nucmedbio.2016.03.002

    Article  CAS  PubMed  Google Scholar 

  13. Fellner, M., Riss, P., Loktionova, N., Zhernosekov, K., Thews, O., Geraldes, C.F.G.C., Kovacs, Z., Lukeš, I., and Rösch, F., Radiochim. Acta, 2011, vol. 99, no. 1, p. 43. https://doi.org/10.1524/ract.2011.1791

    Article  CAS  Google Scholar 

  14. Tadayon, N., Yousefnia, H., Ramazani, A., Zolghadri, S., Alirezapour, B., Jalilian, A.R., Afarideh, H., and Vaez-Tehrani, M., J. Med. Imaging Radiat. Sci., 2019, vol. 50, no. 1, p. 142. https://doi.org/10.1016/j.jmir.2018.10.004

    Article  PubMed  Google Scholar 

  15. Farrell, K.B., Karpeisky, A., Thamm, D.H., and Zinnen, S., Bone Rep., 2018, vol. 9, p. 47. https://doi.org/10.1016/j.bonr.2018.06.007

    Article  PubMed  PubMed Central  Google Scholar 

  16. Mirzaei, A., Jalilian, A.R., Badbarin, A., Mazidi, M., Mirshojaei, F., Geramifar, P., and Beiki, D., Ann. Nucl. Med., 2015, vol. 29, no. 6, p. 506. https://doi.org/10.1007/s12149-015-0971-9

    Article  CAS  PubMed  Google Scholar 

  17. Tsebrikova, G.S., Baulin, V.E., Kalashnikova, I.P., Ragulin, V.V., Zavel’skii, V.O., Kodina, G.E., and Tsivadze, A.Y., Russ. J. Gen. Chem., 2016, vol. 86, no. 3, p. 639. https://doi.org/10.1134/s107036321603021x

    Article  CAS  Google Scholar 

  18. Larenkov, A.A., Mitrofanov, Yu.A., Maruk, A.Ya., Kodina, G.E., Ragulin, V.V., Tsebrikova, G.S., and Baulin, V.E., Abstract of Papers, XIII konf. molodykh uchenykh, aspirantov i studentov IPCE RAN (XIII Conf. Young Scientists, Graduate Students, and Students of IPCE RAS), Moscow, 2018, p. 224.

  19. Bauwens, M., Chekol, R., Vanbilloen, H., Bormans, G., and Verbruggen, A., Nucl. Med. Commun., 2010, vol. 31, no. 8, p. 753. https://doi.org/10.1097/MNM.0b013e32833acb99

    Article  CAS  PubMed  Google Scholar 

  20. Morfin, J.F. and Tóth, É., Inorg. Chem., 2011, vol. 50, no. 20, p. 10371. https://doi.org/10.1021/ic201445e

    Article  CAS  PubMed  Google Scholar 

  21. Haynes, W.M., Lide, D.R., and Brun, T.J., CRCHandbook of Chemistry and Physics, Boca Raton: CRC Press, 2017.

  22. Ogawa, K., Mukai, T., Arano, Y., Otaka, A., Ueda, M., Uehara, T., Magata, Y., Hashimoto, K., and Saji, H., Nucl. Med. Biol., 2006, vol. 33, no. 4, p. 513. https://doi.org/10.1016/j.nucmedbio.2006.03.006

    Article  CAS  PubMed  Google Scholar 

  23. Song, X., Wang, Y., Zhang, J., Jin, Z., and Zhang, Z., Int. J. Lab. Hematol., 2016, vol. 38, no. 1, p. 42. https://doi.org/10.1111/cbdd.13117

    Article  CAS  Google Scholar 

  24. Bai, H.S., Jin, H.X., Fan, H.Q., Du, J., Wang, F., Chen, D.M., and Cheng, Z., J. Radioanal. Nucl. Chem., 1998, vol. 236, nos. 1–2, p. 87. https://doi.org/10.1007/BF02386323

    Article  CAS  Google Scholar 

  25. Moiseenko, V.M. and Blinov, N.N., Sovremennaya taktika lecheniya bol’nykh so zlokachestvennymi novoobrazovaniyami s metastazami v kosti: posobie dlya vrachei (Modern Tactics of Treating Patients with Malignant Neoplasms with Bone Metastases: A Manual for Doctors), St. Petersburg: Ministerstvo Zdravoohraneniya RF, NII Onkologii im. N.N. Petrova, 1996.

  26. Voloznev, L.V., Klement’eva, O.E., Korsunskii, V.N., and Lysenko, N.P., Molekul. Med., 2013, vol. 2, p. 42.

    Google Scholar 

  27. Larenkov, A.A., Bruskin, A.B., and Kodina, G.E., J. Radioanal. Nucl. Chem., 2015, vol. 305, no. 1, p. 147. https://doi.org/10.1007/s10967-015-4089-2

    Article  CAS  Google Scholar 

  28. Larenkov, A.A., Maruk, A.Ya., and Kodina, G.E., Radiochemistry, 2018, vol. 60, no. 6, p. 625. https://doi.org/10.1134/s0134347518060104

    Article  CAS  Google Scholar 

  29. Fellner, M., Biesalski, B., Bausbacher, N., Kubícek, V., Hermann, P., Rösch, F., and Thews, O., Nucl. Med. Biol., 2012, vol. 39, no. 7, p. 993. https://doi.org/10.1016/j.nucmedbio.2012.04.007

    Article  CAS  PubMed  Google Scholar 

  30. Meckel, M., Bergmann, R., Miederer, M., and Roesch, F., EJNMMI Radiopharm. Chem., 2017, vol. 1, no. 1, p. 1. https://doi.org/10.1186/s41181-016-0017-1

    Article  Google Scholar 

  31. Palisaitis, D., Love, M., Zimmerman, R., Radhakrishnan, S., Welsh, R., Saw, J., Renner, S., Kells, C., and Schampaert, E., Can. J. Cardiol., 2011, vol. 27, no. 6, p. 865. https://doi.org/10.1016/j.cjca.2011.06.009

    Article  PubMed  Google Scholar 

Download references

Funding

This study was financially supported by the Russian Foundation for Basic Research (project no. 19-03-00262, synthesis of ligands) and the Russian Science Foundation (project no. 19-13-00294, radiochemical and biological studies).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Iu. A. Mitrofanov.

Ethics declarations

No conflict of interest was declared by the authors.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mitrofanov, I.A., Maruk, A.Y., Larenkov, A.A. et al. Evaluation of Applicability of Aminodiphosphonic Acids for the Development of Bone-Seeking 68Ga-Radiopharmaceuticals. Russ J Gen Chem 90, 390–397 (2020). https://doi.org/10.1134/S107036322003010X

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S107036322003010X

Keywords:

Navigation