Abstract
The binding of 68Ga to two organic ligands containing aminodiphosphonic groups (1,7-diamino-4-oxaheptane-1,1,7,7-tetraphosphonic and 1,7-diamino-4-hydroxycarbonylheptane-1,1,7,7-tetraphosphonic acids) has been examined. The stability and osteotropic potential of the labeled compounds have been evaluated.
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This study was financially supported by the Russian Foundation for Basic Research (project no. 19-03-00262, synthesis of ligands) and the Russian Science Foundation (project no. 19-13-00294, radiochemical and biological studies).
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Mitrofanov, I.A., Maruk, A.Y., Larenkov, A.A. et al. Evaluation of Applicability of Aminodiphosphonic Acids for the Development of Bone-Seeking 68Ga-Radiopharmaceuticals. Russ J Gen Chem 90, 390–397 (2020). https://doi.org/10.1134/S107036322003010X
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DOI: https://doi.org/10.1134/S107036322003010X