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Synthesis and Cytotoxic Activity of a Number of Functionalized 2,3-Allenoates

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Abstract

A series of new functionalized allenoates has been synthesized, and their cytotoxic effect has been studied against the tumor cell line (HepG2 and Jurkat) and the normal origin cells (HEK293). The highest cytotoxic effect has been shown for diterpene-containing allenic compounds, which can be attributed to promising substances with potential antitumor activity.

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ACKNOWLEDGMENTS

The study was performed using the equipment of the Center for Collective Use “Chemistry” (UFRC RAS) and “Biomica” (Department of Biochemical Research Methods and Nanobiotechnology, Region Center for Collective Use “Agidel” Ufa).

Funding

The work was supported by the State program АААА-А17-117011910025-6 and a grant from the Russian Foundation of Basic Research no. 18-53-41004.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, UFRC RAS, Republic of Bashkortostan, 450054, Ufa, Russia

    R. N. Malikova, I. M. Sakhautdinov & M. S. Yunusov

  2. Institute of Biochemistry and Genetics, UFRS RAS, Republic of Bashkortostan, 450054, Ufa, Russia

    M. A. Maksimova, U. Sh. Kuzmina & Yu. V. Vakhitova

Authors
  1. R. N. Malikova
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  2. I. M. Sakhautdinov
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  3. M. A. Maksimova
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  4. U. Sh. Kuzmina
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  5. Yu. V. Vakhitova
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  6. M. S. Yunusov
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Corresponding author

Correspondence to I. M. Sakhautdinov.

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This article does not contain studies that use humans and animals as objects of research.

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The authors state that there is no conflict of interest.

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Translated by A. Levina

Abbreviations: MPI, maleopimarimide; PHTI, phthalimide.

Corresponding author: phone: +7 (906) 104-48-19; e-mail: ioh039@mail.ru.

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Malikova, R.N., Sakhautdinov, I.M., Maksimova, M.A. et al. Synthesis and Cytotoxic Activity of a Number of Functionalized 2,3-Allenoates. Russ J Bioorg Chem 46, 115–119 (2020). https://doi.org/10.1134/S1068162020010057

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  • DOI: https://doi.org/10.1134/S1068162020010057

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