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Differential Pulse Voltammetric Determination of Anticancer Drug Regorafenib at a Carbon Paste Electrode: Electrochemical Study and Density Functional Theory Computations

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Abstract

Electrochemical properties of regorafenib (REG) were studied in 0.1 M Britton−Robinson buffer-methanol solutions (3 : 2, v/v) with pH between 3 and 8 at carbon paste electrode by cyclic and differential pulse voltammetry. The results exhibited irreversible anodic peak at about 0.90 V vs. Ag/AgCl, NaCl (3 M). The anodic peak was found to be diffusion–adsorption controlled. Mechanism of REG electrochemical reaction was studied by performing density functional theory computations and mass spectrometric analysis. A validated differential pulse voltammetry (DPV) technique for REG determination was performed. The calibration curve of REG on carbon paste electrode was linear in the concentration range of 0.5–13 μg/mL and limit of detection was 0.10 µg/mL. The recommended DPV method was used to detect REG in spiked plasma and urine specimens and average recoveries were 94%.

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ACKNOWLEDGMENTS

We wish to thank Bayer for supplying regorafenib and TUBITAK ULAKBIM, High Performance and Grid Computing Center (TR-Grid e-Infrastructure) for the calculations reported in the theoretical part of this paper. We also thank to Uğur BOZKAYA for using Gaussian 09 program package.

Funding

This work was supported by Scientific Research Project Coordination Unit of Istanbul University, Project numbers: PYP-17194 and BEK-2017-25714.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Pharmacy, Istanbul University, 34116, Beyazıt, Istanbul, Turkey

    Zeynep Aydoğmuş & Serap Saglik Aslan

  2. Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, 34469, Maslak, Istanbul, Turkey

    Gülcemal Yildiz

  3. Department of Chemistry, Gebze Technical University, 41400, Gebze, Kocaeli, Turkey

    Ahmet Senocak

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  1. Zeynep Aydoğmuş
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  2. Serap Saglik Aslan
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  3. Gülcemal Yildiz
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Correspondence to Zeynep Aydoğmuş.

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Zeynep Aydoğmuş, Aslan, S.S., Yildiz, G. et al. Differential Pulse Voltammetric Determination of Anticancer Drug Regorafenib at a Carbon Paste Electrode: Electrochemical Study and Density Functional Theory Computations. J Anal Chem 75, 691–700 (2020). https://doi.org/10.1134/S1061934820050032

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  • DOI: https://doi.org/10.1134/S1061934820050032

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