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Development of a Biocompatible and Biodegradable Polymer Capable of Long-Term Release of Biologically Active Substances for Medicine and Agriculture

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Abstract

A process was developed for producing biocompatible and biodegradable polymer films based on high-molecular-weight polylactide with properties necessary for medical and agricultural applications. A method was devised for the inclusion of active substances (gentamicin sulfate, lincomycin hydrochloride, or cefotaxime) into high-molecular-weight polylactide films. The rate of release of active substances from polylactide can vary with time according to a decaying exponential law or nearly linearly. The release of active substances is significantly affected by pH of the solution surrounding the film. It was found that the dynamics of release of active substances from biocompatible biodegradable polymer films based on high-molecular-weight polylactide depends on the properties of the immobilized substance, the film preparation method, and the conditions of extraction. The biocompatible biodegradable polymer films based on high-molecular-weight polylactide are quite suitable for the manufacture of coatings for stents and prostheses with prolonged and controlled drug release into the surrounding tissues and for agricultural applications to improve crop preservation.

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REFERENCES

  1. Sevost’yanov, M.A., Nasakina, E.O., Baikin, A.S., et al., J. Mater. Sci. Mater. Med., 2018, vol. 29, p. 33.

    Article  Google Scholar 

  2. Vu, K.D., Hollingsworth, R.G., Leroux, E., et al., Food Res. Int., 2011, vol. 44, pp. 198–203.

    Article  CAS  Google Scholar 

  3. Boo, G.J., Grijpma, D.W., Moriarty, T.F., et al., Biomaterials, 2015, vol. 52, pp. 113–125.

    Article  Google Scholar 

  4. Sevost’yanov, M.A., Baikin, A.S., Nasakina, E.O., et al., Usp. Sovrem. Estestvoznan., 2016, no. 5, pp. 43–46.

  5. Gritsch, L., Conoscenti, G., La Carrubba, V., et al., Mater. Sci. Eng. C, 2019, vol. 94, pp. 1083–1101.

    Article  CAS  Google Scholar 

  6. Scaffaro, R., Lopresti, F., Marino, A., et al., Appl. Microbiol. Biotechnol., 2018, vol. 102, pp. 7739–7756.

    PubMed  Google Scholar 

  7. Maiborodin, I.V., Kuznetsova, I.V., Shevela, A.I., et al., Morfologiya, 2014, vol. 146, pp. 78–89.

    CAS  Google Scholar 

  8. Ezzat, W.H. and Keller, G.S., Facial Plast. Surg., 2011, vol. 27, pp. 503–509.

    Article  CAS  Google Scholar 

  9. Saffer, E.M., Tew, G.N., and Bhatia, S.R., Curr. Med. Chem., 2011, vol. 18, pp. 5676–5686.

    Article  CAS  Google Scholar 

  10. Shue, L., Yufeng, Z., and Mony, U., Biomatter, 2012, vol. 2, pp. 271–277.

    Article  Google Scholar 

  11. Ehtezazi, T. and Washington, C., J. Control. Release, 2000, vol. 68, pp. 361–372.

    Article  CAS  Google Scholar 

  12. Xie, J., Li, A., and Li, J., Macromol. Rapid. Commun., 2017, vol. 38, p. 23.

    Google Scholar 

  13. Gudkov, S.V., Guryev, E.L., Gapeyev, A.B., et al., Nanomedicine, 2019, vol. 15, pp. 37–46.

    Article  CAS  Google Scholar 

  14. Chernov, A.S., Reshetnikov, D.A., Kovalitskaya, Yu.A., et al., J. Photochem. Photobiol. B, 2018, vol. 188, pp. 77–86.

    Article  CAS  Google Scholar 

  15. Nasakina, E.O., Baikin, A.S., Sergienko, K.V., et al., Dokl. Chem., 2015, vol. 461, part 1, pp. 86–88.

    Article  CAS  Google Scholar 

Download references

Funding

The study was performed within the State Assignment no. 075‒00746‒19‒00 and was partially supported by a grant of the President of the Russian Federation for State Support of Young Russian Scientists MD-3811.2018.11. The spectroscopic part was supported by the research project “Physical Methods in Agriculture and Ecology” (no. 0024‒2019‒0004).

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Authors and Affiliations

  1. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, 119334, Moscow, Russia

    A. S. Baikin, M. A. Kaplan, E. O. Nasakina, A. M. Tsareva, A. A. Kolmakova, E. A. Danilova,  A. G. Kolmakov & M. A. Sevostyanov

  2. Voronezh State Technical University, 394026, Voronezh, Russia

    L. A. Shatova

  3. Bauman Moscow State Technical University (National Research University), 105043, Moscow, Russia

    Ya. A. Tishurova & N. F. Bunkin

  4. Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow, Russia

    Ya. A. Tishurova, N. F. Bunkin & S. V. Gudkov

  5. Lobachevsky State University of Nizhny Novgorod— National Research University, Nizhny Novgorod, Russia

    S. V. Gudkov

  6. All-Russian Research Institute of Phytopathology, Bolshie Vyazemy, Moscow oblast, Russia

    S. V. Gudkov, A. P. Glinushkin & M. A. Sevostyanov

  7. Mari State University, Yoshkar-Ola, Russia

    K. N. Belosludtsev

  8. Ugresha Branch, State University “Dubna”, Dzerzhynsk, Moscow oblast, Russia

    M. A. Sevostyanov

Authors
  1. A. S. Baikin
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  2. M. A. Kaplan
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  3. E. O. Nasakina
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  4. L. A. Shatova
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  5. A. M. Tsareva
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  6. A. A. Kolmakova
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  7. E. A. Danilova
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  8. Ya. A. Tishurova
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  9. N. F. Bunkin
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  10. S. V. Gudkov
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  11. K. N. Belosludtsev
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  12. A. P. Glinushkin
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  13. A. G. Kolmakov
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  14. M. A. Sevostyanov
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Corresponding author

Correspondence to A. S. Baikin.

Additional information

Translated by Z. Svitanko

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Baikin, A.S., Kaplan, M.A., Nasakina, E.O. et al. Development of a Biocompatible and Biodegradable Polymer Capable of Long-Term Release of Biologically Active Substances for Medicine and Agriculture. Dokl Chem 489, 261–263 (2019). https://doi.org/10.1134/S0012500819110041

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  • DOI: https://doi.org/10.1134/S0012500819110041

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