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BY 4.0 license Open Access Published by De Gruyter March 31, 2020

Inflammation, iron and vitamin D metabolism in different cardiomyopathy aetiologies

  • Lukas Lanser , Nada Nemati , Markus Seifert , Dietmar Fuchs , Günter Weiss , Gerhard Pölzl and Katharina Kurz EMAIL logo
From the journal Pteridines

Abstract

Immune activation coincides with disturbances in iron and vitamin D metabolism in patients with cardiomyopathy. In this study, we investigated whether there are differences regarding immune activation, iron and vitamin D metabolism between the different cardiomyopathy aetiologies.

Patients and methods: Parameters of iron metabolism (haemoglobin, iron, transferrin, transferrin saturation, ferritin, hepcidin), vitamin D metabolism (Ct-FGF23, parathormone, phosphate, vitamin D) and immune activation (C-reactive protein and neopterin) were determined in 149 patients (98 men, 51 women) with non-ischaemic cardiomyopathy.

Results: Patients with amyloid cardiomyopathy presented with higher neopterin, ferritin and hepcidin levels than other cardiomyopathy aetiologies. Furthermore, they showed the highest rate of cardiovascular events. C-reactive protein levels were significantly higher in patients with inflammatory cardiomyopathy. Patients with virus positive cardiomyopathy presented with significantly higher ferritin and Ct-FGF23 levels compared to patients with virus negative inflammatory cardiomyopathy.

Conclusion: This study indicates that there are some differences regarding the extent of immune activation and inflammation as well as alterations in iron metabolism disorders between different cardiomyopathy aetiologies. Further studies with larger patient cohorts are needed to investigate these findings more precisely.

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Received: 2019-06-25
Accepted: 2020-02-19
Published Online: 2020-03-31

© 2020 Lukas Lanser et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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