Abstract
Metronidazole (MNZ) is one of the pharmaceutical products which is considered as one of the most important pollutants in the environment due to its wide use and resistance to biodegradation. Hence, the purpose of this study is the optimization of the electrochemical degradation of the metronidazole (MNZ) antibiotic using electrochemical oxidation on a stainless steel316 coated with beta lead oxide (SS316/β-PbO2) anode. In the studied electrochemical process, the response surface methodology (RSM) involving a five-level ((pH (A) and electrolysis time (B), current density (C), and MNZ concentration (D)). The central composite design (CCD) was employed for optimizing and modeling of the electrochemical process in the degradation of MNZ. The preparation of SS316/β-PbO2 anode was accomplished using the electro-deposition method. Scanning electron microscope (SEM), energy-dispersive X-ray (EDX), and X-ray diffraction (XRD) analyses were conducted for accurate evaluation and characterization of the coated electrode. The effect of influencing factors on electrochemical degradation of MNZ was studied, and the highest MNZ degradation efficiency was observed to be 98.88% after 120 min under the optimal conditions including the supporting electrolyte concentration of 1.0 g/100 cc, the initial MNZ concentration of 30.1 mg/L, pH of 4 and the current density of 9.99 mA/cm2. The linear regression coefficient (R2) between experiments and different response values in the model was 0.99. Moreover, the statistical analysis of the results indicated that in the range studied, the most effective parameters in MNZ degradation are MNZ concentration and pH. In general, it can be concluded that the electrochemical process using SS316/β-PbO2 anode can effectively eliminate metronidazole, and it can be considered as an efficient method in the degradation of various pollutants.
Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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