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SYNTHETIC BIOLOGY

Raising the ribosomal repertoire

Nature Chemistry volume 12, pages 503–504 (2020)Cite this article

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Three versatile and mutually orthogonal tRNA/aminoacyl-tRNA synthetase pairs have been developed. Collectively, these pairs enable the site-specific incorporation of three different non-canonical amino acids into a protein that can still be terminated faithfully by a natural stop codon.

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Fig. 1: Mutually orthogonal tRNAPyl/PylRS systems enable advanced protein engineering.

Change history

  • 15 June 2020

    In the originally published PDF version of this News & Views, Fig. 1 was missing codon labels ‘UAG’, ‘AGGA’ and ‘AGUA’. This has now been updated.

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Authors and Affiliations

  1. Biocentre, Departments of Biology and Chemistry, Johannes Gutenberg–University Mainz, Mainz, Germany

    Christopher D. Reinkemeier & Edward A. Lemke

  2. Institute of Molecular Biology, Mainz, Germany

    Christopher D. Reinkemeier & Edward A. Lemke

  3. Structural and Computational Biology Unit and Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany

    Christopher D. Reinkemeier & Edward A. Lemke

Authors
  1. Christopher D. Reinkemeier
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  2. Edward A. Lemke
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Correspondence to Edward A. Lemke.

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Reinkemeier, C.D., Lemke, E.A. Raising the ribosomal repertoire. Nat. Chem. 12, 503–504 (2020). https://doi.org/10.1038/s41557-020-0476-6

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