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Plant-derived endoperoxides: structure, occurrence, and bioactivity

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Abstract

Endoperoxides have received widespread interest as a research topic due to its ubiquitous structure, which confers interesting biological properties. It has been demonstrated that some endoperoxides possess antimalarial, cytotoxic, anti-inflammatory, neuroprotective, antiparasitic, antitumor, and antimicrobial activities. The present review summarizes the current knowledge about the structure, occurrence, peroxide detection methods, stability, biosynthesis, and biological activities of 206 endoperoxides isolated from 1911 to 2019, found in 115 plant species belonging to 36 different plant families. Thirty-five new endoperoxides of different plant species have been reported since the last published review. In order to simplify our analysis, we classified plant endoperoxides considering the nature of the secondary metabolite.

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Abbreviations

11β-HSD1:

11β-Hydroxysteroid dehydrogenase type 1

CCID:

Circular chemo-repellent induced defect

EC50 :

Maximal effective concentration 50%

ED50 :

Effective dose 50%

GI50 :

Growth inhibitory concentration 50%

HBV:

Hepatitis B virus

IC12 :

Inhibitory concentration that gives an inhibition zone of 12 mm

l-NMMA:

N-methyl-l-arginine

LPS:

Lipopolysaccharide

MAP:

Mitogen-activated protein

MIC:

Minimum inhibitory concentration

MLC:

Minimum lethal concentration

NGF:

Nerve growth factor

PDE:

Phosphodiesterase

PKA:

Protein kinase A

ROS:

Reactive oxigen species

SERT:

Serotonin transporter protein

TPA:

12-O-Tetradecanoylphorbol-13-acetate

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  1. Universidad Autonoma de Nuevo Leon, Facultad de Medicina, Avenida Madero y Aguirre Pequeño s/n, Col. Mitras Sur, C.P. 64460, Monterrey, N.L., Mexico

    Juan F. Tamez-Fernández, Elda M. Melchor-Martínez, Tannya R. Ibarra-Rivera & Verónica M. Rivas-Galindo

  2. Instituto Tecnológico y de Estudios Superiores de Monterrey, Campus Monterrey, Avenida Eugenio Garza Sada 2501 Sur, Tecnológico, C.P. 64849, Monterrey, N.L., Mexico

    Elda M. Melchor-Martínez

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Tamez-Fernández, J.F., Melchor-Martínez, E.M., Ibarra-Rivera, T.R. et al. Plant-derived endoperoxides: structure, occurrence, and bioactivity. Phytochem Rev 19, 827–864 (2020). https://doi.org/10.1007/s11101-020-09687-4

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