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Chronic inflammatory changes and oxidative stress in the background of “pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm”

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Abstract

Cases of “pancreatic ductal adenocarcinoma (PDAC) concomitant with intraductal papillary mucinous neoplasm” (IPMN) have multiple PDAC lesions more frequently than cases of “PDAC without IPMN”. However, the mechanism of carcinogenesis in this former disease category remains unknown. The main objective of this work was thus to investigate the effects of chronic inflammation on carcinogenesis in PDAC cases. We selected 31 “PDAC concomitant with IPMN” patients and 58 “PDAC without IPMN” patients and pathologically evaluated their background pancreatic parenchyma. Fibrosis and inflammation scores of background pancreas were higher in “PDAC concomitant with IPMN” than in “PDAC without IPMN” (P < 0.0001 and P < 0.0001, respectively), whereas the fatty infiltration score of background pancreas was high in “PDAC without IPMN” (P = 0.0024). Immunohistochemically, the expression of 8-hydroxy-2′-deoxyguanosine (8-OHDG), an oxidative stress marker, in the background pancreas was high in “PDAC concomitant with IPMN” compared with that in “PDAC without IPMN” (P < 0.0001). Chronic inflammation activates oxidative stress in tissue throughout the pancreas and probably confers susceptibility to tumorigenesis in “PDAC concomitant with IPMN”.

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Acknowledgements

Technical support for the experimental trials was provided by Miwako Ishii as a laboratory assistant. This article was proofread by Scientific Language Co., Ltd.

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Authors and Affiliations

  1. Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Ryota Matsuda, Yuichi Yamada, Jun Kawata, Kukiko Sakihama, Takeo Yamamoto, Kiyoshi Saeki, Hidetaka Yamamoto, Yutaka Koga & Yoshinao Oda

  2. Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Ryota Matsuda, Yoshihiro Miyasaka, Jun Kawata, Kukiko Sakihama, Takeo Yamamoto, Kiyoshi Saeki & Masafumi Nakamura

  3. Department of Surgery, Fukuoka University Chikushi Hospital, Chikushino, Japan

    Yoshihiro Miyasaka

  4. Department of Diagnostic Pathology, Iizuka Hospital, Iizuka, Japan

    Yoshihiro Ohishi

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  1. Ryota Matsuda
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Contributions

Conceptualization: Ryota Matsuda, Yoshihiro Miyasaka, Yuichi Yamada, Hidetaka Yamamoto; Methodology: Ryota Matsuda, Yoshihiro Miyasaka; Formal analysis and investigation: Ryota Matsuda, Jun Kawata, Kukiko Sakihama, Takeo Yamamoto, Kiyoshi Saeki, Yoshihiro Ohishi, Yutaka Koga; Writing—original draft preparation: Ryota Matsuda; Writing—review and editing: Yoshihiro Miyasaka, Masafumi Nakamura, Yoshinao Oda; Supervision: Yoshinao Oda.

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Correspondence to Yoshinao Oda.

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This study was approved by the Ethics Committee of Kyushu University (institutional review board approval no. 29-505) and conducted in accordance with the Helsinki Declaration.

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Matsuda, R., Miyasaka, Y., Yamada, Y. et al. Chronic inflammatory changes and oxidative stress in the background of “pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm”. Virchows Arch 477, 799–806 (2020). https://doi.org/10.1007/s00428-020-02844-2

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