Whereas textbooks depict metabolism in perfect homeostasis, disturbances occur in real life. One particularly relevant disturbance, caused by excess food and alcohol consumption and exacerbated by genetics, is reductive stress. New work by Goodman et al. identifies a biomarker of reductive stress and uses a gene therapy solution in mice. This work suggests how exercise and an accessible nutritional technology can synergistically increase catabolism and relieve reductive stress.
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References
Zhao, Y. et al. Nat. Protoc. 11, 1345–1359 (2016).
Goodman, R. P. et al. Nature https://doi.org/10.1038/s41586-020-2337-2 (2020).
Sullivan, L. B. et al. Cell 162, 552–563 (2015).
Liu, X., Romero, I. L., Litchfield, L. M., Lengyel, E. & Locasale, J. W. Cell Metab. 24, 728–739 (2016).
Gall, W. E. et al. PLoS ONE 5, e10883 (2010).
Trammell, S. A. J. et al. Sci. Rep. 6, 26933 (2016).
Diguet, N. et al. Circulation 137, 2256–2273 (2018).
Bieganowski, P. & Brenner, C. Cell 117, 495–502 (2004).
Fluharty, N. & Brenner, C. Am. J. Clin. Nutr. (in the press).
Cracan, V., Titov, D. V., Shen, H., Grabarek, Z. & Mootha, V. K. Nat. Chem. Biol. 13, 1088–1095 (2017).
Patgiri, A. et al. Nat. Biotechnol. 38, 309–313 (2020).
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C.B. owns stock in, and is chief scientific adviser to, ChromaDex, Inc. C.D.H. declares no competing interests.
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Heer, C.D., Brenner, C. Letting off electrons to cope with metabolic stress. Nat Metab 2, 485–486 (2020). https://doi.org/10.1038/s42255-020-0207-8
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DOI: https://doi.org/10.1038/s42255-020-0207-8
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Lifespan extension with preservation of hippocampal function in aged system xc−-deficient male mice
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