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The Role of High-Density Lipoproteins in Maintaining Osmotic Homeostasis in the Goldfish Carassius auratus L. (Cyprinidae)

  • Comparative and Ontogenic Biochemistry
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Journal of Evolutionary Biochemistry and Physiology Aims and scope Submit manuscript

Abstract

A hypothesis on the involvement of high-density lipoproteins (HDL) in maintaining osmotic homeostasis in fish was proposed. For its verification, structural reorganizations of serum HDL in the goldfish Carassius auratus L. were investigated under natural conditions (during the seasonal dynamics) and in experiments on the effect of critical salinity. A common algorithm of HDL rearrangements in wild freshwater fish and those acclimated experimentally to critical salinity was established. It consists in reversible dissociation–association of HDL particles. In the natural (freshwater) habitat, this algorithm is congruent with the dynamics of total protein distribution across the capillary wall, while under experimental conditions with changes in water salinity. These findings imply the possibility of multiple strategies of maintaining osmotic homeostasis with the involvement of HDL in higher teleosts the blood of which, in contrast to mammals, lacks a specialized osmotically active protein albumin. The role of HDL as universal metabolic regulators and stabilizers is discussed.

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Funding

This work was implemented within a state assignment to Papanin Institute for Biology of Inland Waters of the Russian Academy of Sciences (AAAA-A18-118012690123-4) and supported by the Russian Foundation for Basic Research (grant no. 16-04-00120-a).

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Authors and Affiliations

  1. I.D. Papanin Institute for Biology of Inland Waters, Russian Academy of Sciences, Borok, Russia

    A. M. Andreeva, D. V. Garina, N. E. Lamash & A. S. Vasiliev

  2. V.N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Sciences, Moscow, Russia

    I. Yu. Toropygin

  3. A.V. Zhirmunsky National Scientific Center for Marine Biology, Russian Academy of Sciences, Vladivostok, Russia

    N. E. Lamash

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  1. A. M. Andreeva
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  2. I. Yu. Toropygin
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  3. D. V. Garina
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  4. N. E. Lamash
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  5. A. S. Vasiliev
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Correspondence to A. M. Andreeva.

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All applicable international, national and institutional principles of handling and using experimental animals for scientific purposes were observed. This study did not involve human subjects as research objects.

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Andreeva, A.M., Toropygin, I.Y., Garina, D.V. et al. The Role of High-Density Lipoproteins in Maintaining Osmotic Homeostasis in the Goldfish Carassius auratus L. (Cyprinidae). J Evol Biochem Phys 56, 102–112 (2020). https://doi.org/10.1134/S0022093020020027

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  • DOI: https://doi.org/10.1134/S0022093020020027

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