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The Influence of Perinatal Stress and Antidepressants on Different Types of Adaptive Behavior and Cognitive Abilities of Prepubertal Female Rats

  • Comparative and Ontogenic Physiology
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Abstract

We investigated the influence of repeated peripheral inflammatory nociceptive stimulation of neonate female rats born to mothers exposed during pregnancy to chronic stress and the effect of an antidepressant drug fluoxetine, a selective serotonin (5-HT) reuptake inhibitor, and an anxiolytic drug buspirone, a 5-HT1A receptor agonist, on adaptive behavior and cognitive abilities of the offspring during the prepubertal period. The data on the effect of maternal stress exposure during the critical perinatal period of individual development on adaptive behavior and spatial learning abilities of the offspring provide support for the hypothesis on the possible beneficial effect of moderate stressful events experienced at an early age on stress tolerance in subsequent ontogenesis. The corrective effect of the above drugs on adaptive behavior and cognitive abilities of the prenatally stressed prepubertal female offspring exposed to repeated peripheral inflammatory pain at the neonatal stage is characterized.

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Funding

This work was supported by the Russian Foundation for Basic Research (project no. 17-04-00214a).

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    I. P. Butkevich, V. A. Mikhailenko & E. A. Vershinina

  2. Pediatric Medical University, St. Petersburg, Russia

    I. P. Butkevich

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  1. I. P. Butkevich
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  2. V. A. Mikhailenko
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  3. E. A. Vershinina
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Correspondence to I. P. Butkevich.

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All applicable international, national and institutional principles of handling and using experimental animals for scientific purposes were observed. This study did not involve human subjects as research objects.

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Butkevich, I.P., Mikhailenko, V.A. & Vershinina, E.A. The Influence of Perinatal Stress and Antidepressants on Different Types of Adaptive Behavior and Cognitive Abilities of Prepubertal Female Rats. J Evol Biochem Phys 56, 133–144 (2020). https://doi.org/10.1134/S0022093020020052

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