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Biosynthesis of Silver–Silver Chloride Nanoparticles Using Fruit Extract of Levisticum Officinale: Characterization and Anticancer Activity Against MDA-MB-468 Cell Lines

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Abstract

In this study, characterization and anticancer activity of synthesized silver and silver chloride nanoparticles (Ag–AgCl NPs) using aqueous fruit extract of Levisticum Officinale were investigated. The first sign of the synthesis of Ag–AgCl NPs was the color change of the solution from yellow to brown due to the addition of plant extract to the silver nitrate (AgNO3) solution, which was confirmed by UV–Vis spectroscopy. The phase and chemical characteristics, size, spherical shape, nanocrystalline structure and stability of Ag–AgCl NPs were evaluated by fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray analysis (EDX), transmission electron microscope (TEM), scanning electron microscopy (SEM), dynamic light scattering (DLS), X-Ray diffraction (XRD) and zeta potential analyzes. The results confirmed the formation of spherical nanoparticles with the face centered cubic (FCC) crystalline structure. The cytotoxic effect of Ag–AgCl on MDA-MB-468 cancer cell line was studied by 3-[4,5 dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) colorimetric method at 48 h. Also, MTT assay results prove promising that the Ag–AgCl NPs could be an agent of breast cancer treatment.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, Shahid Bahonar University of Kerman, Kerman, Iran

    Roshana Sattari & Gholam Reza Khayati

  2. Mahani Mathematical Research Center, Shahid Bahonar University of Kerman, Box No. 76135-133, Kerman, Iran

    Gholam Reza Khayati

  3. Department of Microbiology and Molecular Genetics, Biomedical Physical Sciences, Michigan State University, East Lansing, MI, 48824, USA

    Reyhane Hoshyar

  4. Cellular and Molecular Research Center, Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran

    Reyhane Hoshyar

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  1. Roshana Sattari
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  2. Gholam Reza Khayati
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  3. Reyhane Hoshyar
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Correspondence to Gholam Reza Khayati.

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Sattari, R., Khayati, G.R. & Hoshyar, R. Biosynthesis of Silver–Silver Chloride Nanoparticles Using Fruit Extract of Levisticum Officinale: Characterization and Anticancer Activity Against MDA-MB-468 Cell Lines. J Clust Sci 32, 593–599 (2021). https://doi.org/10.1007/s10876-020-01818-3

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  • DOI: https://doi.org/10.1007/s10876-020-01818-3

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