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Transient renal dysfunction due to rhabdomyolysis after robot-assisted radical prostatectomy

  • Urology - Original Paper
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Abstract

Purpose

The aim of the present study was to investigate whether renal dysfunction following rhabdomyolysis occurs after robot-assisted radical prostatectomy (RARP), and to investigate the factors related to rhabdomyolysis after RARP.

Methods

A total of 180 consecutive patients who underwent RARP at our institution were investigated. Rhabdomyolysis was defined as creatine kinase (CK) > 1050 IU/L after RARP. The association between CK and renal function after RARP was investigated, and the factors related to rhabdomyolysis after RARP were also investigated.

Results

Postoperative CK (407 ± 936 IU/L) was significantly higher than preoperative CK (134 ± 75 IU/L) (p < 0.001), and eGFR after RARP was significantly negatively correlated with CK on the day after RARP (correlation coefficient (ρ) = − 0.248, p = 0.007), but the significant negative correlation disappeared on the 7th day after RARP (ρ = − 0.010, p = 0.32). On multivariate analysis, postoperative CK elevation was significantly correlated with console time (p = 0.002). Rhabdomyolysis was observed in 6.1% (11/180), and of the patients with rhabdomyolysis, acute renal failure was transiently observed in 45.5% (5/11). On multivariate analysis, rhabdomyolysis was significantly associated with higher body mass index (BMI) (> 25.7 kg/m2) and longer console time (> 188 min) (p = 0.02 and p = 0.005, respectively).

Conclusion

Temporary renal dysfunction can occur after RARP due to CK elevation. Thus, sufficient attention must be paid to renal insufficiency after elevation of CK values for several days after RARP. Because rhabdomyolysis after RARP was associated with both obesity and long console time, console time during RARP should be shortened, especially in patients with obesity.

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Acknowledgements

The author thanks everyone involved in this paper.

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Authors and Affiliations

  1. Department of Urology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan

    Akifumi Onagi, Ryo Tanji, Ruriko Honda, Kanako Matsuoka, Seiji Hoshi, Tomoyuki Koguchi, Jyunya Hata, Yuichi Sato, Hidenori Akaihata, Masao Kataoka, Soichiro Ogawa & Yoshiyuki Kojima

  2. Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    Nobuhiro Haga

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  1. Akifumi Onagi
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Correspondence to Akifumi Onagi.

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Onagi, A., Haga, N., Tanji, R. et al. Transient renal dysfunction due to rhabdomyolysis after robot-assisted radical prostatectomy. Int Urol Nephrol 52, 1877–1884 (2020). https://doi.org/10.1007/s11255-020-02500-3

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