Abstract
Feline morbillivirus (FeMV) is an emerging member of the family Paramyxoviridae that is suspected to be involved in chronic kidney disease (CKD). FeMV was first discovered in Hong Kong in 2012 and has subsequently been detected in many countries. However, the prevalence of FeMV in mainland China is still unclear. To clarify the present status and examine the genetic diversity of FeMV in mainland China, in this study, we collected cat urine samples in veterinary hospitals in Guangdong Province in 2017 and 2018. Using reverse transcription (RT)-PCR, we found that the urine of six out of 64 cats tested positive for FeMV RNA. Sequencing and genetic analysis of the FeMV L gene showed that FeMV in mainland China is genetically diverse, and phylogenetic analysis showed that the viruses segregated into two clusters. Two isolates, GD5 and GD6, grouped in a branch that was separate from the one containing other previously reported FeMV isolates. These results will contribute to a better understanding of the evolution of FeMV in China.
References
Rima B, Balkema-Buschmann A, Dundon WG, Duprex P, Easton A, Fouchier R, Kurath G, Lamb R, Lee B, Rota P, Wang L, Ictv RC (2019) ICTV virus taxonomy profile: paramyxoviridae. J Gen Virol 100:1593–1594
Chua KB, Bellini WJ, Rota PA, Harcourt BH, Tamin A, Lam SK, Ksiazek TG, Rollin PE, Zaki SR, Shieh W, Goldsmith CS, Gubler DJ, Roehrig JT, Eaton B, Gould AR, Olson J, Field H, Daniels P, Ling AE, Peters CJ, Anderson LJ, Mahy BW (2000) Nipah virus: a recently emergent deadly paramyxovirus. Science 288:1432–1435
Meli ML, Simmler P, Cattori V, Martinez F, Vargas A, Palomares F, Lopez-Bao JV, Simon MA, Lopez G, Leon-Vizcaino L, Hofmann-Lehmann R, Lutz H (2010) Importance of canine distemper virus (CDV) infection in free-ranging Iberian lynxes (Lynx pardinus). Vet Microbiol 146:132–137
Sato H, Yoneda M, Honda T, Kai C (2012) Morbillivirus receptors and tropism: multiple pathways for infection. Front Microbiol 3:75
Sieg M, Busch J, Eschke M, Bottcher D, Heenemann K, Vahlenkamp A, Reinert A, Seeger J, Heilmann R, Scheffler K, Vahlenkamp TW (2019) A New Genotype of Feline Morbillivirus Infects Primary Cells of the Lung, Kidney, Brain and Peripheral Blood. Viruses 11(2):146. https://doi.org/10.3390/v11020146
Sutummaporn K, Suzuki K, Machida N, Mizutani T, Park ES, Morikawa S, Furuya T (2019) Association of feline morbillivirus infection with defined pathological changes in cat kidney tissues. Vet Microbiol 228:12–19
Woo PC, Lau SK, Wong BH, Fan RY, Wong AY, Zhang AJ, Wu Y, Choi GK, Li KS, Hui J, Wang M, Zheng BJ, Chan KH, Yuen KY (2012) Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats. Proc Natl Acad Sci USA 109:5435–5440
Darold GM, Alfieri AA, Muraro LS, Amude AM, Zanatta R, Yamauchi KC, Alfieri AF, Lunardi M (2017) First report of feline morbillivirus in South America. Arch Virol 162:469–475
Furuya T, Sassa Y, Omatsu T, Nagai M, Fukushima R, Shibutani M, Yamaguchi T, Uematsu Y, Shirota K, Mizutani T (2014) Existence of feline morbillivirus infection in Japanese cat populations. Arch Virol 159:371–373
Furuya T, Morikawa S, Miyazawa T (2016) Discovery and current research status of feline morbillivirus. Uirusu 66:147–154
Lorusso A, Di Tommaso M, Di Felice E, Zaccaria G, Luciani A, Marcacci M, Aste G, Boari A, Savini G (2015) First report of feline morbillivirus in Europe. Vet Ital 51:235–237
Park ES, Suzuki M, Kimura M, Mizutani H, Saito R, Kubota N, Hasuike Y, Okajima J, Kasai H, Sato Y, Nakajima N, Maruyama K, Imaoka K, Morikawa S (2016) Epidemiological and pathological study of feline morbillivirus infection in domestic cats in Japan. BMC Vet Res 12:228
Sharp CR, Nambulli S, Acciardo AS, Rennick LJ, Drexler JF, Rima BK, Williams T, Duprex WP (2016) Chronic infection of domestic cats with feline morbillivirus, United States. Emerg Infect Dis 22:760–762
Yilmaz H, Tekelioglu BK, Gurel A, Bamac OE, Ozturk GY, Cizmecigil UY, Altan E, Aydin O, Yilmaz A, Berriatua E, Helps CR, Richt JA, Turan N (2017) Frequency, clinicopathological features and phylogenetic analysis of feline morbillivirus in cats in Istanbul, Turkey. J Feline Med Surg 19:1206–1214
Donato G et al (2019) Isolation and genome sequences of two Feline Morbillivirus genotype 1 strains from Italy. Vet Ital 55(2):179–182
Stranieri A et al (2019) Feline morbillivirus in Northern Italy: prevalence in urine and kidneys with and without renal disease. Vet Microbiol 233:133–139
Mohd IN et al (2019) Molecular detection and characterisation of feline morbillivirus in domestic cats in Malaysia. Vet Microbiol 236:108382
Funding
This work was supported by the National Natural Science Foundation of China (31372448, 31672563), the Special Fund for Agro-Scientific Research in the Public Interest (201303042), the National Key Research and Development Program of China (2016YFD0501004, 2016YFD0501010), the Promote Scientific and Technological Development Program (2013B040200032), and the Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases (2013A061401013).
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Ou, J., Ye, S., Xu, H. et al. First report of feline morbillivirus in mainland China. Arch Virol 165, 1837–1841 (2020). https://doi.org/10.1007/s00705-020-04649-9
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DOI: https://doi.org/10.1007/s00705-020-04649-9