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The role of miRNA-155 in monocrotaline-induced pulmonary arterial hypertension through c-Fos/NLRP3/caspase-1

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Abstract

Background

Nisoldipine can effectively suppress pulmonary arterial smooth muscle cell proliferation and c-Fos expression.

Objective

To identify the mechanism of the anti-inflammatory effects in monocrotaline-induced pulmonary arterial hypertension (PAH), focusing on the c-Fos/NLRP3/caspase-1 pathway.

Results

In a mice model of monocrotaline-induced PAH, miRNA-155 expression was increased. In an in vitro model, overexpression of miRNA-155 promoted inflammation and induced c-Fos, NLRP3, and caspase-1 protein expression. The inhibition of c-Fos reduced the effects of miRNA-155 on inflammation in an in vitro model of monocrotaline-induced PAH. The inhibition of NLRP3 reduced the effects of miRNA-155 on inflammation in an in vitro model of monocrotaline-induced PAH.

Conclusions

miRNA-155 increased inflammation in monocrotaline-induced PAH through c-Fos/NLRP3/caspase-1.

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Authors and Affiliations

  1. Department of Cardiac Surgery, Liaocheng People’s Hospital, Liaocheng, 252000, Shandong, People’s Republic of China

    Shou-Dong Chai, Zhen-Kun Li, Rui Liu, Tao Liu, Ming-Feng Dong, Pei-Zhe Tang, Jian-Tang Wang & Sheng-Jun Ma

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  1. Shou-Dong Chai
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  2. Zhen-Kun Li
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  3. Rui Liu
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  4. Tao Liu
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  5. Ming-Feng Dong
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  6. Pei-Zhe Tang
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  7. Jian-Tang Wang
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  8. Sheng-Jun Ma
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Correspondence to Sheng-Jun Ma.

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Chai, SD., Li, ZK., Liu, R. et al. The role of miRNA-155 in monocrotaline-induced pulmonary arterial hypertension through c-Fos/NLRP3/caspase-1. Mol. Cell. Toxicol. 16, 311–320 (2020). https://doi.org/10.1007/s13273-020-00083-9

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  • DOI: https://doi.org/10.1007/s13273-020-00083-9

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