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Hematological malignancies in Ukraine in post-Chernobyl era: sources of data and their preliminary analysis

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Abstract

The major sources of the data on the hematological malignancies in the post-Chernobyl period in the regions of Ukraine differing by the levels of the residual contamination with radionuclides have been analyzed. According to the data collected from the primary hematological facilities in Ukraine in 2010–2017, the incidence of lymphoid neoplasms from mature B cells, acute myeloid leukemia, and multiple myeloma in the most contaminated regions was higher than in the less contaminated ones. For the first time, the relative contribution of the several specific types of leukemia in the total diagnosed hematological malignancies has been analyzed throughout 1997–2017 based on the in-house database compiled by the Reference Laboratory of RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, the National Academy of Sciences of Ukraine. In 2011–2017, the Reference Laboratory provided the diagnostic studies in about 26% of all Ukrainian patients with tumors of hematopoietic and lymphoid tissues (34% of patients with different forms of acute and chronic leukemia). The increased proportion of acute myeloid leukemia and chronic lymphocytic leukemia in the total diagnosed cases of overall leukemia in the patients from contaminated regions has been demonstrated following Chernobyl accident.

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Notes

  1. Annually published in Ukraine in 2010–2017 as a series of Institute in-house reference booklets “Indicators of hematological service activity in Ukraine”

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Acknowledgments

The authors thank Dr. Z.P. Fedorenko and Dr. L.B. Kutsenko, National Cancer Registry of Ukraine, National Institute of Cancer of the Ministry of Health of Ukraine, for the supporting materials and valuable advice in preparation of the manuscript.

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Authors and Affiliations

  1. RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, the National Academy of Sciences of Ukraine, Kyiv, Ukraine

    Stella V. Koval, Daniil F. Gluzman, Lilia M. Sklyarenko, Tetiana S. Ivanivska, Mykhailo P. Zavelevich & Alex A. Philchenkov

  2. Institute for Nuclear Research, the National Academy of Sciences of Ukraine, Kyiv, Ukraine

    Nataliia K. Rodionova

  3. SI “Institute of Blood Pathology and Transfusion Medicine of the National Academy of Medical Sciences of Ukraine”, Lviv, Ukraine

    Vasyl L. Novak, Zvenislava V. Masliak & Yaroslava I. Vyhovska

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  1. Stella V. Koval
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  2. Daniil F. Gluzman
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  3. Lilia M. Sklyarenko
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  4. Tetiana S. Ivanivska
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  5. Mykhailo P. Zavelevich
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  6. Alex A. Philchenkov
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  7. Nataliia K. Rodionova
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Corresponding author

Correspondence to Daniil F. Gluzman.

Ethics declarations

All studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, the National Academy of Sciences of Ukraine and the Institutional Committee on Bioethics of IEPOR and the Ethics and Deontology Committee of the Institute of Blood Pathology and Transfusion Medicine of the NAMS of Ukraine. Informed consent was obtained from all individual participants included in the study.

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Koval, S.V., Gluzman, D.F., Sklyarenko, L.M. et al. Hematological malignancies in Ukraine in post-Chernobyl era: sources of data and their preliminary analysis. Ann Hematol 99, 1543–1550 (2020). https://doi.org/10.1007/s00277-020-04076-5

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  • DOI: https://doi.org/10.1007/s00277-020-04076-5

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