Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

MicroRNA-628-5p Facilitates Enterovirus 71 Infection by Suppressing TRAF3 Signaling

Cellular & Molecular Immunology volume 18, pages 1320–1322 (2021)Cite this article

Subjects

To date, EV71 infection still poses a great challenge to the health of infants and young children.1 Much established evidence suggests that EV71 infection depends on a wide variety of host factors, including cell surface receptors for EV71 entry, innate immune response, miRNAs, and lncRNAs.2,3 It is thought that diverse signaling pathways are required for EV71 to escape the host immune response.4 Innate immunity serves as the first line of defense against pathogens. Tumor necrosis factor receptor-associated factor (TRAF) proteins are essential components of signaling pathways activated by Toll-like receptor (TLR) or RIG-I-like receptor (RLR) family members. TRAF3 is widely expressed by many cell types, including all nucleated immune cells, in which it plays many roles in the regulation of immune functions.5 TRAF3 plays a significant role in regulating the functions of B and T lymphocytes. TRAF3 is a highly versatile regulator that positively controls type I interferon and cytokine production through interferon regulatory factors (IRFs) and nuclear factor-κB (NF-κB).6 A recent study indicated that EV71-induced ubiquitin-specific protease 19 (USP19) negatively regulates type I IFN signaling by targeting TRAF3.7

Currently, increasing attention has been paid to the roles of miRNAs in the EV71-host interaction. Upregulation of miR-493-3p8 and the miR-302 cluster9 suppresses the EV71-induced innate immune response via direct targeting of PTEN and karyopherin α2 (KPNA2), respectively. However, the functional roles of other miRNAs during EV71 infection remain largely unknown. In addition, the significance of these miRNAs needs to be addressed in clinical settings in EV71-infected patients.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1

References

  1. Lee, J. T. et al. Enterovirus 71 seroepidemiology in Taiwan in 2017 and comparison of those rates in 1997, 1999 and 2007. PloS One 14, e0224110 (2019).

    Article  CAS  Google Scholar 

  2. Jin, Y., Zhang, R., Wu, W. & Duan, G. Antiviral and inflammatory cellular signaling associated with enterovirus 71 infection. Viruses 10, 155 (2018).

    Article  Google Scholar 

  3. Li, Y. et al. Characterization of critical functions of long non-coding RNAs and mRNAs in rhabdomyosarcoma cells and mouse skeletal muscle infected by enterovirus 71 using RNA-Seq. Viruses 10, 556 (2018).

    Article  Google Scholar 

  4. Jin, Y., Zhang, R., Wu, W. & Duan, G. Innate immunity evasion by enteroviruses linked to epidemic hand-foot-mouth disease. Front Microbiol 9, 2422 (2018).

    Article  Google Scholar 

  5. Hildebrand, J. M. et al. Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions. Immunol. Rev. 244, 55–74 (2011).

    Article  CAS  Google Scholar 

  6. Hacker, H., Tseng, P. H. & Karin, M. Expanding TRAF function: TRAF3 as a tri-faced immune regulator. Nat. Rev. Immunol. 11, 457–468 (2011).

    Article  Google Scholar 

  7. Gu, Z., Shi, W., Zhang, L., Hu, Z. & Xu, C. USP19 suppresses cellular type I interferon signaling by targeting TRAF3 for deubiquitination. Future Microbiol 12, 767–779 (2017).

    Article  CAS  Google Scholar 

  8. Zhao, Q. et al. Host MicroRNA hsa-miR-494-3p promotes EV71 replication by directly targeting PTEN. Front Cell Infect. Microbiol 8, 278 (2018).

    Article  Google Scholar 

  9. Peng, N. et al. MicroRNA-302 cluster downregulates enterovirus 71-induced innate immune response by targeting KPNA2. J. Immunol. 201, 145–156 (2018).

    Article  CAS  Google Scholar 

  10. Li, M. et al. MiR-628-5p decreases the tumorigenicity of epithelial ovarian cancer cells by targeting at FGFR2. Biochem Biophys. Res Commun. 495, 2085–2091 (2018).

    Article  CAS  Google Scholar 

  11. Srivastava, A. et al. Circulatory miR-628-5p is downregulated in prostate cancer patients. Tumour Biol. 35, 4867–4873 (2014).

    Article  CAS  Google Scholar 

  12. Xu, Z. et al. Dysregulated MicroRNA expression and chronic lung allograft rejection in recipients with antibodies to donor HLA. Am. J. Transpl. 15, 1933–1947 (2015).

    Article  CAS  Google Scholar 

  13. Squillace, N. et al. Changes in subcutaneous adipose tissue microRNA expression in HIV-infected patients. J. Antimicrob. Chemother. 69, 3067–3075 (2014).

    Article  CAS  Google Scholar 

  14. Jia, H. L. et al. MicroRNA expression profile in exosome discriminates extremely severe infections from mild infections for hand, foot and mouth disease. BMC Infect. Dis. 14, 506 (2014).

    Article  Google Scholar 

  15. Cui, L. et al. Serum microRNA expression profile distinguishes enterovirus 71 and coxsackievirus 16 infections in patients with hand-foot-and-mouth disease. PLoS One 6, e27071 (2011).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was funded by the National Natural Science Foundation of China (No. 81172740 and No. 81573205 to G.C.D.); Project founded by China Postdoctoral Science Foundation (No. 2019M662543 to Y.F.J.); and High-level Talent Start-up Funding of Zhengzhou University (No. 141-32340042 to W.G.Z.).

Author information

Author notes

  1. These authors contributed equally: Dong Li, Shuaiyin Chen

Authors and Affiliations

  1. Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, People’s Republic of China

    Dong Li, Shuaiyin Chen, Weiguo Zhang, Chao Zhang, Tiantian Sun, Yue Du, Ronghua Ding, Yanlei Gao, Yuefei Jin & Guangcai Duan

  2. Department of Immunology, Duke University Medical Center, Durham, NC, 27710, USA

    Weiguo Zhang

Authors
  1. Dong Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shuaiyin Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Weiguo Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Chao Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tiantian Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yue Du
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ronghua Ding
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yanlei Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Yuefei Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Guangcai Duan
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

G.C.D., Y.F.J., D.L. and S.Y.C. conceived and designed the research; D.L., C.Z., T.T.S., Y.D., R.H.D., and Y.L.G. performed the research; Y.F.J. and D.L. analyzed the data; and the manuscript was written by Y.F.J. and D.L. and revised by W.G.Z.

Corresponding authors

Correspondence to Yuefei Jin or Guangcai Duan.

Ethics declarations

Competing interests

The authors declare no competing interests.

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, D., Chen, S., Zhang, W. et al. MicroRNA-628-5p Facilitates Enterovirus 71 Infection by Suppressing TRAF3 Signaling. Cell Mol Immunol 18, 1320–1322 (2021). https://doi.org/10.1038/s41423-020-0453-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41423-020-0453-4

This article is cited by

Search

Advanced search

Quick links