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A Case of STK4 Deficiency with Complications Evoking Mycobacterial Infection

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Fig. 1
Fig. 2

Abbreviations

CNS:

Central nervous system

FOXO1:

Forkhead box protein O1

HSCT:

Hematopoietic stem cell transplantation

INH:

Isonizaid

IVIG:

Intravenous immunoglobulin

MST1:

Mammalian sterile 20-like protein

STK4:

Serine/threonine protein kinase

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Acknowledgments

Authors would like to acknowledge Raif Geha, Janet Chou, and Craig Platt (Boston Children’s Hospital, Harvard Medical School, Boston, USA) for performing the genetic sequencing using NGS and its confirmation by Sanger sequencing.

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Authors and Affiliations

  1. Paediatric Allergy and Immunology Unit, Children’s Hospital, Ain Shams University, Cairo, Egypt

    Nesrine Radwan, Rasha El-Owaidy, Zeinab A. El-Sayed, Ashraf Abdel-Baky, Elham Hossny & Shereen Medhat Reda

  2. Children’s Cancer Hospital, Egypt (CCHE-57357), Cairo, Egypt

    Alaa El-Haddad, Hanaa Rashad & Eman Naguib Khorshed

  3. National Cancer Institute, Cairo, Egypt

    Alaa El-Haddad & Eman Naguib Khorshed

  4. Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA

    Craig D. Platt, Jacqueline G. Wallace & Janet Chou

Authors
  1. Nesrine Radwan
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  2. Rasha El-Owaidy
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  3. Zeinab A. El-Sayed
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  4. Ashraf Abdel-Baky
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  5. Alaa El-Haddad
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  6. Hanaa Rashad
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  7. Eman Naguib Khorshed
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  8. Craig D. Platt
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  9. Jacqueline G. Wallace
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  10. Janet Chou
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  11. Elham Hossny
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  12. Shereen Medhat Reda
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Contributions

NR and SMR shared in following up the patient clinically and in writing and reviewing the paper equally.

R El-O, ZA, AA, and EH shared in following up the patient clinically.

HR and AH were following up the patient in CCHE-57357.

ENK was responsible for the pathology reviewing of the patient.

JC, CP, and JW were responsible on the molecular diagnostic part.

All authors reviewed and edited the paper.

Corresponding author

Correspondence to Nesrine Radwan.

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The authors declare that they have no conflict of interest.

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Capsule Summary

We present an extended clinical phenotype of a patient with STK4 deficiency associated with mycobacterial infection.

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Radwan, N., El-Owaidy, R., El-Sayed, Z.A. et al. A Case of STK4 Deficiency with Complications Evoking Mycobacterial Infection. J Clin Immunol 40, 665–669 (2020). https://doi.org/10.1007/s10875-020-00783-w

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  • DOI: https://doi.org/10.1007/s10875-020-00783-w

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