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Increased plasma level of apelin with NYHA grade II and III but not IV

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Abstract

The change in plasma apelin level in heart failure (HF) patients is controversial. We investigated the change in plasma apelin level in HF patients versus control and non-HF patients. The plasma level of apelin was measured by ELISA and plasma level of B-type natriuretic peptide (BNP) by fluorescence immunoassay. We included 101 patients with HF, 32 patients without HF and 20 controls. The three groups did not differ in general and clinical characteristics. Plasma levels of apelin and BNP were both higher in HF patients than non-HF patients and controls. Plasma levels of apelin and BNP were not correlated. Plasma level of BNP was increased with increasing New York Heart Association grade and apelin level was decreased. Apelin level was lower in HF patients with NYHA grade IV than in controls and non-HF patients. Apelin level had 75% diagnostic value for HF, and BNP level had 96.8% diagnostic value. At a cutoff of 6.44 ng/mL apelin level, sensitivity was 69.3%, and specificity 97.1%. However, the diagnostic of apelin for NYHA II patients was higher than that of BNP (99.6% vs. 96.1%). These results suggested that apelin might be particularly useful in association with BNP in mild HF patients.

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Acknowledgements

This study was funded by the National Natural Science Foundation of China (Nos. 81670434, 81770499, 31872790), and Project for training excellent talents of Xicheng District in Beijing (No. 80004126).

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Authors and Affiliations

  1. Department of Cardiology, Fu Xing Hospital, Capital Medical University, Beijing, 100038, China

    Ling Han, Bingzhang Jie, Jingguang Luo, Liwei Chen, Ye Jia, Like Guo, Yan Zhao, Xin Chen & Xiaogang Zhu

  2. Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, School of Basic Medical Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Haidian District, Beijing, 100191, China

    Yongfen Qi

  3. Hebei Key Laboratory of Laboratory Animal Science, Department of Physiology, Hebei Medical University, No. 361 Zhongshan East Road, Changan District, Shijiazhuang, 050017, Hebei, China

    Xu Teng

  4. Hebei Collaborative Innovation Center for Cardio–cerebrovascular Disease, Shijiazhuang, 050017, China

    Xu Teng

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  1. Ling Han
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  2. Bingzhang Jie
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  7. Yan Zhao
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  10. Xu Teng
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  11. Yongfen Qi
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by LH, BJ, JL, LC, YJ, LG, YZ, XC and XZ. The first draft of the manuscript was written by XT and YQ, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Xu Teng or Yongfen Qi.

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Research involving human participants and/or animals

This study involved human participants. It was approved by the Ethics Committee of Capital Medical University, and conducted according to the 1964 Helsinki declaration and its later amendments

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Han, L., Jie, B., Luo, J. et al. Increased plasma level of apelin with NYHA grade II and III but not IV. Amino Acids 52, 823–829 (2020). https://doi.org/10.1007/s00726-020-02855-y

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