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Heterophilic antibodies influence immunometric assay: a case report and reviews

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References

  1. Lippi G, Aloe R, Meschi T, Borghi L, Cervellin G. Interference from heterophilic antibodies in troponin testing: case report and systematic review of the literature. Clin Chim Acta. 426(2013):79–84.

  2. Lippi G, Ardission D, Aloe R, Cervellin G. A false positive case of cardiac troponin I identified with CK-MB reflex testing. Int J Cardiol. 2014;176:e3–4.

    Article  Google Scholar 

  3. Zaid A, Cowell R. False positive cardiac troponin elevation due to heterophile antibodies: more common than we recognize? BMJ Case Rep. 2010;15:2010.

    Google Scholar 

  4. Bjerner J, Nustad K, Norum LF, Olsen KH, Bormer OP. Immunometric assay interference: incidence and prevention. Clin Chem. 2002;48(4):613–21.

    Article  CAS  Google Scholar 

  5. Ingegnoil F, Castelli R, Gualtierotti R. Rheumatoid factors: clinical applications. Hindawi Publishing Corporation Disease Markers. 2013;35(6):727–34.

    Article  Google Scholar 

  6. Lupoli GA, Barba L, Liotti A, La Civita E, Lupoli R, Riccio E, et al. Falsely elevated thyroglobulin and calcitonin due to rheumatoid factor in non-relapsing thyroid carcinoma: a case report. Medicine. 2019;98:5.

    Article  Google Scholar 

  7. Tan SY, Bracha A. Rosalyn Yalow (1921–2011): Madame Curie from the Bronx. Singap Med J. 2019;60(7):337–8.

    Article  Google Scholar 

  8. Wu AHB. A selected history and future of immunoassay development and applications in clinical chemistry. Clin Chim Acta. 2006;369:119–24.

    Article  CAS  Google Scholar 

  9. Bolstad N, Warren DJ, Nustad K. Heterophilic antibody interference in immunometric assays. Best Pract Reas Clin Endocrinol Metab. 2013;27:647–61.

    Article  CAS  Google Scholar 

  10. Prince HE, Lapé-Nixon M, Givens TS, Bradshaw T, Nowicki MJ. Elimination of falsely reactive results in a commercially-available West Nile virus IgM capture enzyme-linked immunosorbent assay by heterophilic antibody blocking reagents. J Immunol Methods. 2017;444:24–8.

    Article  CAS  Google Scholar 

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Acknowledgments

We profoundly thank our cardiologist Dr. Liu for a great support to the diagnosis which was not AMI.

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Correspondence to Yao-Feng Hu.

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Hu, YF., Ho, SY. Heterophilic antibodies influence immunometric assay: a case report and reviews. Immunol Res 68, 104–106 (2020). https://doi.org/10.1007/s12026-020-09128-6

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