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SIRP-α instructs alveolar macrophages to stop eating after pneumonia

Nature Immunology volume 21, pages 601–603 (2020)Cite this article

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Injury or infection renders patients vulnerable to secondary pneumonia. A new study indicates that SIRP-α triggers prolonged impairment of the phagocytic capacity of alveolar macrophages after the resolution of primary bacterial or viral pneumonia.

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Fig. 1: Alveolar macrophages (AMs) exhibit long-term functional impairment after primary bacterial pneumonia, caused by a SIRP-α-dependent mechanism.

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Authors and Affiliations

  1. Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands

    Alex F. de Vos & Tom van der Poll

  2. Division of Infectious Diseases, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands

    Tom van der Poll

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  1. Alex F. de Vos
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  2. Tom van der Poll
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Correspondence to Tom van der Poll.

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The authors declare no competing interests.

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de Vos, A.F., van der Poll, T. SIRP-α instructs alveolar macrophages to stop eating after pneumonia. Nat Immunol 21, 601–603 (2020). https://doi.org/10.1038/s41590-020-0680-y

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