Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

SOMATIC MUTATIONS

Clonal competition in a confined space

Many normal tissues are populated by clonal expansions that compete for space. Colom et al. now show that mutant clones keep other mutant clones in check by effectively annulling one another’s advantages.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Clonal dynamics in normal tissue.

References

  1. Nowak, M. A. et al. Proc. Natl Acad. Sci. USA 99, 16226–16231 (2002).

    Article  CAS  Google Scholar 

  2. Nowak, M. A., Michor, F. & Iwasa, Y. Proc. Natl Acad. Sci. USA 100, 14966–14969 (2003).

    Article  CAS  Google Scholar 

  3. Martincorena, I. et al. Science 348, 880–886 (2015).

    Article  CAS  Google Scholar 

  4. Zhu, M. et al. Cell 177, 608–621.e12 (2019).

    Article  CAS  Google Scholar 

  5. Lee-Six, H. et al. Nature 574, 532–537 (2019).

    Article  CAS  Google Scholar 

  6. Yoshida, K. et al. Nature 578, 266–272 (2020).

    Article  CAS  Google Scholar 

  7. Yokoyama, A. et al. Nature 565, 312–317 (2019).

    Article  CAS  Google Scholar 

  8. Brunner, S. F. et al. Nature 574, 538–542 (2019).

    Article  CAS  Google Scholar 

  9. Moore, L. et al. Nature 580, 640–646 (2020).

    Article  CAS  Google Scholar 

  10. Colom, B. et al. Nat. Genet. https://doi.org/10.1038/s41588-020-0624-3 (2020).

  11. Martincorena, I. et al. Science 3879, eaau3879 (2018).

    Google Scholar 

  12. Martincorena, I. Genome Med. 11, 35 (2019).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kamila Naxerova.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Naxerova, K. Clonal competition in a confined space. Nat Genet 52, 553–554 (2020). https://doi.org/10.1038/s41588-020-0638-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-020-0638-x

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing