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Tetraspanins in mammalian reproduction: spermatozoa, oocytes and embryos

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A Correction to this article was published on 20 June 2020

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Abstract

It is known that tetraspanin proteins are involved in many physiological somatic cell mechanisms. Additionally, research has indicated they also have a role in various infectious diseases and cancers. This review focuses on the molecular interactions underlying the tetraspanin web formation in gametes. Primarily, tetraspanins act in the reproductive tract as organizers of membrane complexes, which include the proteins involved in the contact and association of sperm and oocyte membranes. In addition, recent data shows that tetraspanins are likely to be involved in these processes in a complex way. In mammalian fertilization, an important role is attributed to CD molecules belonging to the tetraspanin superfamily, particularly CD9, CD81, CD151, and also CD63; mostly as part of extracellular vesicles, the significance of which and their potential in reproduction is being intensively investigated. In this article, we reviewed the existing knowledge regarding the expression of tetraspanins CD9, CD81, CD151, and CD63 in mammalian spermatozoa, oocytes, and embryos and their involvement in reproductive processes, including pathological events.

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Acknowledgements

This work was supported by the Scientific Grant Agency of the Ministry of Education, Science, Research, and Sport of the Slovak Republic and the Slovak Academy of Sciences (VEGA-2/0027/20), by the Slovak Research and Development Agency (APVV-15-0196), bilateral project SAS-CAS (18-17); by the Internal Grant Agency of Czech University of Life Sciences in Prague (SV18-08-21230); by the CellFit COST Action CA16119, Ministry of Education, Youth and Sports, Czech Republic INTER-COST LTC 18059; by the Grant Agency of the Czech Republic No. GA-18-11275S; by the project BIOCEV (CZ.1.05/1.1.00/02.0109) from the ERDF; and by the Institutional support of the Institute of Biotechnology RVO: 86652036.

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  1. Jana Jankovičová and Zdeňka Neuerová authors contributed equally to this work.

Authors and Affiliations

  1. Laboratory of Reproductive Physiology, Center of Biosciences, Institute of Animal Biochemistry and Genetics, Slovak Academy of Sciences, Bratislava, Slovak Republic

    Jana Jankovičová, Petra Sečová, Michaela Bartóková & Jana Antalíková

  2. Laboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic

    Zdeňka Neuerová, Kateřina Komrsková & Pavla Postlerová

  3. Faculty of Science, University of Hradec Králové, Hradec Králové, Czech Republic

    Zdeňka Neuerová

  4. Department of Veterinary Sciences, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Prague, Czech Republic

    Filipa Bubeníčková & Pavla Postlerová

  5. Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic

    Kateřina Komrsková

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Jankovičová, J., Neuerová, Z., Sečová, P. et al. Tetraspanins in mammalian reproduction: spermatozoa, oocytes and embryos. Med Microbiol Immunol 209, 407–425 (2020). https://doi.org/10.1007/s00430-020-00676-0

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