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Immunoglobulin free light chains: an inflammatory biomarker of diabetes

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A Correction to this article was published on 05 June 2020

This article has been updated

Abstract

Objective

Inflammation is increasingly understood as playing an important role in type 2 diabetes mellitus (T2D) development. A critical mechanism of the inflammatory cascade in developing T2D is nuclear factor-kappa B (NF-kB) activation. As immunoglobulin free light chains (FLC) could be a biomarker of activation of NF-kB, we measured FLC in patients with T2D.

Subjects

The age range of the 77 patients with T2D and the 75 healthy control participants were 45–87 years (median 60) and 25–72 years (median 51), respectively.

Methods

Serum FLC kappa and lambda were assayed by a competitive-inhibition multiplex Luminex assay.

Results

The concentration of circulating FLC the kappa/lambda ratio was lower in patients with T2D than in healthy volunteers. The area under the receiver operating curve (ROC-AUC) of the FLC kappa/lambda ratio showed the largest ROC-AUC compared with other FLC variables and hemoglobin A1c (HbA1c). The diagnostic performance for distinguishing between T2D and healthy control was a sensitivity of 0.96 and a specificity of 1. The odds ratio was 0.000018.

Conclusions

These results suggest that FLC kappa/lambda may be more specific and sensitive for the diagnosis of T2D than HbA1c, and thus represents a potentially promising biomarker of inflammation.

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Fig. 1

Change history

  • 05 June 2020

    In the original publication of this paper contains some typographical errors in Table 1.

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Acknowledgements

We thank Dr. Noboru Nabeya for collecting sera and Dr. Steven Tracy for helpful comments.

Funding

There was no specific funding for the study.

Author information

Authors and Affiliations

  1. Clinical Research Center, Kyoto Medical Center, 1-1 Fukakusa Mukaihata-cho, Fushimi-ku, Kyoto, 612-8555, Japan

    Akira Matsumori

  2. Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan

    Toshio Shimada

  3. VCL Laboratory, Osaka, Japan

    Miho Shimada

  4. The University of Birmingham, Birmingham, UK

    Mark T. Drayson

Authors
  1. Akira Matsumori
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  2. Toshio Shimada
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  3. Miho Shimada
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  4. Mark T. Drayson
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Corresponding author

Correspondence to Akira Matsumori.

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Conflict of interest

Mark Drayson has shares in Abingdon Health and has been a paid consultant for them. Other authors declare no conflict of interest.

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Responsible Editor: John Di Battista.

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Matsumori, A., Shimada, T., Shimada, M. et al. Immunoglobulin free light chains: an inflammatory biomarker of diabetes. Inflamm. Res. 69, 715–718 (2020). https://doi.org/10.1007/s00011-020-01357-7

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  • DOI: https://doi.org/10.1007/s00011-020-01357-7

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