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Development and characterization of a PDMS-based masking method for microfabricated Oral drug delivery devices

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Abstract

With the growing popularity and application of microfabricated devices in oral drug delivery (ODD), masking technologies for drug loading and surface modification become highly relevant. Considering the speed of design and fabrication processes and the necessity for continuous alterations of e.g. the shape and sizes of the devices during the optimization process, there is a need for adaptable, precise and low-cost masking techniques. Here, a novel method is presented for masking ODD microdevices, namely microcontainers, using the physical characteristics of polydimethylsiloxane (PDMS). When compared to a rigid microfabricated shadow mask, used for filling drugs in microcontainers, the PDMS masking technique allows more facile and precise loading of higher quantities of an active compound, without the need of alignment. The method provides flexibility and is adjustable to devices fabricated from different materials with various geometries, topologies and dimensions. This user-friendly flexible masking method overcomes the limitations of other masking techniques and is certainly not limited to ODD and is recommended for a wide range of microdevices.

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Acknowledgements

The authors would like to acknowledge the Novo Nordisk Foundation (NNF17OC0026910) for funding the project MIMIO – Microstructures, microbiota and oral delivery and Danmarks Grundforskningsfond og Villum Fondens Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN) whose research is funded by the Danish National Research Foundation (DNRF122) and Villum Fonden (Grant No. 9301).

The authors would like to thank Zarmeena Abid from National Center for Nanofabrication and Characterization, Technical University of Denmark for supplying the PCL microcontainers for this project and Jesper Scheel from the Department of Health Technology, Technical University of Denmark for photography of the PDMS mask fabrication process.

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Funding

This research was financially supported by the Danish National Research Foundation (DNRF122), Villum Fonden (Grant No. 9301) and the Novo Nordisk Foundation (NNF17OC0026910).

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Authors and Affiliations

  1. The Danish National Research Foundation and Villum Foundation’s Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark

    Khorshid Kamguyan, Lasse Højlund Eklund Thamdrup, Lukas Vaut, Line Hagner Nielsen, Kinga Zor & Anja Boisen

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  1. Khorshid Kamguyan
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  2. Lasse Højlund Eklund Thamdrup
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  3. Lukas Vaut
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Correspondence to Khorshid Kamguyan.

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Kamguyan, K., Thamdrup, L.H.E., Vaut, L. et al. Development and characterization of a PDMS-based masking method for microfabricated Oral drug delivery devices. Biomed Microdevices 22, 35 (2020). https://doi.org/10.1007/s10544-020-00490-8

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