Skip to main content

Advertisement

SpringerLink
Log in

Health benefits of chromones: common ingredients of our daily diet

  • Published:
Phytochemistry Reviews Aims and scope Submit manuscript

Abstract

Chromones are naturally occurring phenolic compounds that are universally present in a healthy human diet. To date, thousands of chromone derivatives, including chromone glycosides have been discovered, both from natural and synthetic origin. Many plant genera, including Aloe, Aquilaria, Cassia, Hypericum and Polygonum, are rich sources of chromones. Several genera of fungi, such as Aspergillus, Mycoleptodiscus, Orbiocrella, and Penicillium produce bioactive chromones. This class of compounds is mainly associated with anti-oxidant, antimicrobial, anticancer and anti-inflammatory activities. Various in vitro, in vivo and clinical studies have established the role of chromones in alleviating allergies, reducing oxidative damage, inhibiting cancer, infections and inflammation, and for treating neurological and psychiatric disorders. This review focuses mainly on natural chromones, and elaborates on their nutritional benefits, pharmacological activities, and mechanisms of action. Various scientific databases, including PubMed, Scopus and Google Scholar, were used to find relevant literature on chromones covering all available literature up to, and including the year 2019. This critical analysis of completed research regarding the nutraceutical properties of various chromone derivatives may provide new insight to scientists working in related fields.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Abbreviations

ATP:

Adenosine triphosphate

CC50 :

50% cytotoxic concentration

DMSO:

Dimethyl sulfoxide

DPPH:

2,2-Diphenyl-1-picryl-hydrazyl free radicals

EC50 :

Half maximal effective concentration

fMLF:

Formyl-methionine-leucine-phenylalanine

FPR1:

Formyl peptide receptor-1

GST:

Glutathione S-transferase

HIV:

Human immunodeficiency virus

IC50 :

Half maximal inhibitory concentration to inhibit 50%

IgE:

Immunoglobulin E

i.v. :

Intraveneously

IZD:

Inhibition zone diameter

LPS:

Lipopolysaccharide

MAO:

Monoamine oxidase

MDR:

Multidrug-resistant

MIC:

Minimum inhibitory concentration

MTT:

3-(4,5-Dmethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

NAD+ :

Nicotinamide adenine dinucleotide

NO:

Nitrogen oxide

ROS:

Radical oxygen species

SIRT2:

Sirtuin-2

TLC:

Thin layer chromatography

TNF:

Tumour necrosis factor

UV:

Ultraviolet

References

  • Abe I, Morita H (2010) Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases. Nat Prod Rep 27:809–838

    PubMed  CAS  Google Scholar 

  • Adesogan EK, Okunade AL (1978) Structure of conyzorigun, a new chromone from Ageratum conyzoides. J Chem Soc, Chem Commun 3:152

    Google Scholar 

  • Agrawal A, Singh J (1988) Glycosides of two xanthones and a chromone from roots of Chrozophora prostrate. Phytochemistry 27:3692–3694

    CAS  Google Scholar 

  • Akhtar MS, Kaskoos RA, Mir SR et al (2009) New chromone derivative from Evolvulus alsinoides Linn. aerial parts. J Saudi Chem Soc 13:191–194

    CAS  Google Scholar 

  • An RB, Park BY, Kim JH et al (2005) Coumarins and chromones from Angelica genuflexa. Nat Prod Sci 11:79–84

    CAS  Google Scholar 

  • An RB, Jeong GS, Beom JS et al (2009) Chromone glycosides and hepatoprotective constituents of Hypericum erectum. Arch Pharm Res 32:1393–1397

    PubMed  CAS  Google Scholar 

  • Anh DT, Duong TB, Hoang VD (2014) A new chromone from Hymenocallis littoralis Salisb. (Amaryllidaceae). Nat Prod Res 28:1869–1872

    PubMed  CAS  Google Scholar 

  • Anonymous (2014) Orphan drug status for alvocidib. Oncol Times 36:91

    Google Scholar 

  • Arisawa M, Shiojima M, Bai H et al (1992) Chrysograyanone, a novel chromone derivative from Chrysosplenium grayanum Maxim. Tetrahedron Lett 33:5977–5980

    CAS  Google Scholar 

  • Asamenew G, Bisrat D, Mazumder A et al (2011) In vitro antimicrobial and antioxidant activities of anthrone and chromone from the latex of Aloe harlana Reynolds. Phytother Res 25:1756–1760

    PubMed  CAS  Google Scholar 

  • Augstein J, Cairns H, Hunter D et al (1977) New orally effective chromone derivatives for the treatment of asthma. Agents Actions 7:443–445

    PubMed  CAS  Google Scholar 

  • Avramenko LG, Sklyar YE, Perel’son ME et al (1975) The structure of pilopleurin—a new chromone from Pilopleura kozo-poljanskii. Chem Nat Compd 9:15–16

    Google Scholar 

  • Azuma Y, Yokoyama T, Fukita T et al (1985) Anti-allergic action of 6-ethyl-3-(1H-tetrazol-5-yl) chromone (AA-344) in rats. II. Effect of AA-344 on histamine release from rat peritoneal exudate cells. J Gifu Dental Soc 12:71–77

    CAS  Google Scholar 

  • Baba K, Kawanishi H, Taniguchi M et al (1992) Chromones from Cnidium monnieri. Phytochemistry 31:1367–1370

    CAS  Google Scholar 

  • Baba K, Kawanishi H, Taniguchi M et al (1993) Chromone glucosides from Cnidium japonicum. Phytochemistry 35:221–225

    Google Scholar 

  • Baldé AM, Vanhaelen M, Ottinger R (1987) A chromone from the of Harrisonia abyssinica. Phytochemistry 26:2415–2416

    Google Scholar 

  • Bao J, Luo JF, Qin XC et al (2014a) Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure–bioactivity relationship. Bioorg Med Chem Lett 24:2433–2436

    PubMed  CAS  Google Scholar 

  • Bao J, Zhang XY, Dong JJ et al (2014b) Cyclopentane-condensed chromones from marine-derived fungus Penicillium oxalicum. Chem Lett 43:837–839

    CAS  Google Scholar 

  • Bastide P, Vaudeleau J, Couquelet J et al (1966) On the analgesic activity of some 2-carbonamidochromones. Therapie 21:1361–1369

    PubMed  CAS  Google Scholar 

  • Basudan OA, Ilyas M, Parveen M et al (2005) A new chromone from Ficus lyrata. J Asian Nat Prod Res 7:81–85

    PubMed  CAS  Google Scholar 

  • Bhagavathula AS, Mahmoud Al-Khatib AJ, Elnour AA et al (2015) Ammi visnaga in treatment of urolithiasis and hypertriglyceridemia. Pharmacogn Res. 7:397–400

    CAS  Google Scholar 

  • Bisrat D, Dagne E, Van Wyk BE et al (2000) Chromones and anthrones from Aloe marlothii and Aloe rupestris. Phytochemistry 55:949–952

    PubMed  CAS  Google Scholar 

  • Biswas KM, Mallik H (1986) Cassiadinine, a chromone alkaloid and (+)-6-hydroxy-mellein, a dihydroisocoumarin from Cassia siamea. Phytochemistry 25:1727–1730

    CAS  Google Scholar 

  • Blitzke T, Schmidt J (2001) 7-O-methylaloeresin A—a new chromone glycoside from Commiphora socotrana. Nat Prod Lett 15:27–33

    PubMed  CAS  Google Scholar 

  • Blokhina O, Virolainen E, Fagerstedt KV (2003) Antioxidants, oxidative damage and oxygen deprivation stress: a review. Ann Bot 91:179–194

    PubMed  PubMed Central  CAS  Google Scholar 

  • Bourwieg D, Janistyn B, Stocker M et al (1974) 5-Hydroxy chromone 7-rutinoside in Mentha longifolia Hudson. Arch Pharm 307:131–136

    CAS  Google Scholar 

  • Carola C, Pfluecker F, Graf R et al (2010) Tiliroside and dihydroxy methylchromone: from nature to cosmetic applications. J Appl Cosmetol 28:109–123

    CAS  Google Scholar 

  • Chan WR, Taylor DR, Willis CR (1967) The structure of sorbifolin, a chromone from Spathelia sorbifolia L. J Chem Soc C 2540–2542

  • Chen G, Jin HZ, Li XF et al (2008) A new chromone glycoside from Rhododendron spinuliferum. Arch Pharm Res 31:970–972

    PubMed  CAS  Google Scholar 

  • Chen XQ, Li Y, Cheng X et al (2010) Polycyclic polyprenylated acylphloroglucinols and chromone O-glucosides from Hypericum henryi subsp. uraloides. Chem Biodivers 7:196–204

    PubMed  CAS  Google Scholar 

  • Chen D, Xu Z, Chai X et al (2012) Nine 2-(2-phenylethyl)chromone derivatives from the resinous wood of Aquilaria sinensis and their inhibition of LPS-induced NO production in RAW 264.7 cells. Eur J Org Chem 27:5389–5397

    Google Scholar 

  • Choi S, Lee SK, Kim JE et al (2002) Aloesin inhibits hyperpigmentation induced by UV radiation. Clin Exp Dermatol 27:513–515

    PubMed  CAS  Google Scholar 

  • Cock IE (2015) The genus aloe: phytochemistry and therapeutic uses including treatments for gastrointestinal conditions and chronic inflammation. In: Rainsford KD, Powanda MC, Whitehouse MW (eds) Novel natural products: therapeutic effects in pain, arthritis and gastro-intestinal diseases. Springer, Basel, pp 179–235

    Google Scholar 

  • Conner JM, Gray AI, Reynolds T et al (1989) Anthracene and chromone derivatives in the exudate of Aloe rabaiensis. Phytochemistry 28:3551–3553

    CAS  Google Scholar 

  • Conner JM, Gray AI, Reynolds T et al (1990) Anthrone and chromone components of Aloe cremnophila and A. jacksonii leaf exudates. Phytochemistry 29:941–944

    CAS  Google Scholar 

  • Conrad J, Förster-Fromme B, Constantin MA et al (2009) Flavonoid glucuronides and a chromone from the aquatic macrophyte Stratiotes aloides. J Nat Prod 72:835–840

    PubMed  CAS  Google Scholar 

  • Cui CB, Tezuka Y, Kikuchi T et al (1992) Constituents of a fern, Davallia mariesii Moore. IV. Isolation and structures of a novel norcarotane sesquiterpene glycoside, a chromone glucuronide, and two epicatechin glycosides. Chem Pharm Bull 40:2035–2040

    CAS  Google Scholar 

  • Dahl R (1980) Clinical study of a new orally active chromone in asthma: Proxicromil (FPL 57787). Clin Allergy 10:715–720

    PubMed  CAS  Google Scholar 

  • Dai HF, Liu J, Zeng YB et al (2009) A new 2-(2-phenylethyl)-chromone from Chinese eaglewood. Molecules 14:5165–5168

    PubMed  PubMed Central  CAS  Google Scholar 

  • Dai HF, Liu J, Han Z et al (2010) Two new 2-(2-phenylethyl)chromones from Chinese eaglewood. J Asian Nat Prod Res 12:134–137

    PubMed  CAS  Google Scholar 

  • De Andrade MR, Almeida EX, Conserva LM (1998) Alkyl chromone and other compounds from Clusia nemorosa. Phytochemistry 47:1431–1433

    Google Scholar 

  • De Shan M, An TY, Hu LH et al (2004) Diterpene derivative and chromone from Hypericum perforatum. Nat Prod Res 18:15–19

    PubMed  Google Scholar 

  • Dias MM, Machado NFL, Marques MPM (2011) Dietary chromones as antioxidant agents—the structural variable. Food Funct 2:595–602

    PubMed  CAS  Google Scholar 

  • Djemgou PC, Gatsing D, Tchuendem M et al (2006) Antitumor and immunostimulatory activity of two chromones and other constituents from Cassia petersiana. Nat Prod Commun 1:961–968

    Google Scholar 

  • Donnelly D, Geoghegan R, O’Brien C et al (1965) Synthesis of heterocyclic-substituted chromones and related compounds as potential anticancer agents. J Med Chem 8:872–875

    PubMed  CAS  Google Scholar 

  • Du G, Yang L, Shen Y et al (2013) A new chromone from the flower buds of Magnolia fargesii and its anti HIV-1 activity. Asian J Chem 25:6455–6456

    CAS  Google Scholar 

  • Duan YD, Jiang YY, Guo FX et al (2019) The antitumor activity of naturally occurring chromones: a review. Fitoterapia 135:114–129

    PubMed  CAS  Google Scholar 

  • Edwards AM (2014) Progress in allergy management: chromones. In: Bergmann K-C, Ring J (eds) History of allergy. Chemical immunology and allergy, vol 100. Karger, Basel, pp 317–322

    Google Scholar 

  • Edwards AM, Howell JBL (2000) The chromones: history, chemistry and clinical development. A tribute to the work of Dr REC Altounyan. Clin Exp Allergy 30(6):756–774

    PubMed  CAS  Google Scholar 

  • Ellis GP, Shaw D (1972) Benzopyrones. 7. Synthesis and antiallergic activity of some 2-(5-tetrazolyl)chromones. J Med Chem 15:865–867

    PubMed  CAS  Google Scholar 

  • Engelhart CA, Aldrich CC (2013) Synthesis of chromone, quinolone, and benzoxazinone sulfonamide nucleosides as conformationally constrained inhibitors of adenylating enzymes required for siderophore biosynthesis. J Org Chem 78:7470–7481

    PubMed  PubMed Central  CAS  Google Scholar 

  • Feng BM, Pei YH, Hua HM (2002a) A new chromone derivative from Stellera chamaejasme L. Chin Chem Lett 13:738–739

    CAS  Google Scholar 

  • Feng Y, Blunt JW, Cole ALJ et al (2002b) The isolation of two new chromone derivatives from the New Zealand fungus Tolypocladium extinguens. J Nat Prod 65:1681–1682

    PubMed  CAS  Google Scholar 

  • Forghieri M, Laggner C, Paoli P et al (2009) Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors. Bioorg Med Chem 17:2658–2672

    PubMed  CAS  Google Scholar 

  • Fujimoto H, Nozawa M, Okuyama E et al (2002) Five new chromones possessing monoamine oxidase inhibitory activity from an Ascomycete, Chaetomium quadrangulatum. Chem Pharm Bull 50:330–336

    CAS  Google Scholar 

  • Gamal-Eldeen AM, Djemgou PC, Tchuendem M et al (2007) Anti-cancer and immunostimulatory activity of chromones and other constituents from Cassia petersiana. Z Naturforsch C 62:331–338

    PubMed  CAS  Google Scholar 

  • Gamal-Eldeen AM, Abdel-Lateff A, Okino T (2009) Modulation of carcinogen metabolizing enzymes by chromanone A; a new chromone derivative from algicolous marine fungus Penicillium sp. Env Toxicol Pharmacol 28:317–322

    CAS  Google Scholar 

  • Gaspar A, Reis J, Fonseca A et al (2011) Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors. Bioorg Med Chem Lett 21:707–709

    PubMed  CAS  Google Scholar 

  • Gaspar A, Matos MJ, Garrido J et al (2014) Chromone: a valid scaffold in medicinal chemistry. Chem Rev 114:4960–4992

    PubMed  CAS  Google Scholar 

  • Ghosal S, Kumar Y, Singh S et al (1983) Biflorin, a chromone-C-glucoside from Pancratium biflorum. Phytochemistry 22:2591–2593

    CAS  Google Scholar 

  • Girard JP, Sullivan TJ (1980) The effect of proxicromil, a new oral chromone derivative, in antigen challenge tests in asthmatic patients. Clin Allergy 10:271–276

    PubMed  CAS  Google Scholar 

  • Gobbi S, Hu Q, Zimmer C et al (2016) Exploiting the chromone scaffold for the development of inhibitors of corticosteroid biosynthesis. J Med Chem 59:2468–2477

    PubMed  CAS  Google Scholar 

  • Gonzalez AG, Fraga BM, Pino O (1974) A new chromone from the stems of Cneorum tricoccum. Phytochemistry 13:2305–2307

    Google Scholar 

  • González AG, Fraga BM, Pino O (1975) Pulverin, a new chromone from the fruits of Neochamaelea pulverulenta. Phytochemistry 14:1656–1657

    Google Scholar 

  • Gunn R, Hailes H (2008) Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules. J Chem Biol 1:49–62

    PubMed  PubMed Central  Google Scholar 

  • Guo Z, She Z, Shao C et al (2007) 1H and13C NMR signal assignments of Paecilin A and B, two new chromone derivatives from mangrove endophytic fungus Paecilomyces sp. (tree 1-7). Magn Reson Chem 45:777–780

    PubMed  CAS  Google Scholar 

  • Han L, Zheng F, Zhang Y et al (2015) Triglyceride accumulation inhibitory effects of new chromone glycosides from Drynaria fortune. Nat Prod Res 29:1703–1710

    PubMed  CAS  Google Scholar 

  • Hikisz P, Szczupak Ł, Koceva-Chyła A et al (2015) Anticancer and antibacterial activity studies of gold(I)-alkynyl chromones. Molecules 20:19699–19718

    PubMed  PubMed Central  CAS  Google Scholar 

  • Holgate ST, Edwards AM (2003) The chromones: cromolyn sodium and nedocromil sodium. In: Adkinson NF, Yunginger JW, Busse WW et al (eds) Middleton’s allergy: principles and practice, 6th edn. Mosby, St. Louis, p 915

    Google Scholar 

  • Holzapfel CW, Wessels PL, Van Wyk BE et al (1997) Chromone and aloin derivatives from Aloe broomii, A. africana and A. speciosa. Phytochemistry 45:97–102

    CAS  Google Scholar 

  • Houghton PJ (2000) Chemistry and biological activity of natural and semi-synthetic chromone alkaloids. Stud Nat Prod Chem 21:123–155

    CAS  Google Scholar 

  • Houghton PJ, Hairong Y (1987) Further chromone alkaloids from Schumanniophyton magnificum. Planta Med 53:262–264

    PubMed  CAS  Google Scholar 

  • Houghton PJ, Woldemariam TZ, Khan AI et al (1994) Antiviral activity of natural and semi-synthetic chromone alkaloids. Antivir Res 25:235–244

    PubMed  CAS  Google Scholar 

  • Howell J (2005) Roger Altounyan and the discovery of cromolyn (sodium cromoglycate). J Allergy Clin Immunol 115:882–885

    PubMed  Google Scholar 

  • Hu QF, Zhou B, Gao XM et al (2012) Antiviral chromones from the stem of Cassia siamea. J Nat Prod 75:1909–1914

    PubMed  CAS  Google Scholar 

  • Huang M, Li J, Liu L et al (2016) Phomopsichin A–D; Four new chromone derivatives from mangrove endophytic fungus Phomopsis sp. 33#. Mar Drugs 14:215

    PubMed Central  Google Scholar 

  • Hussain H, Krohn K, Draeger S et al (2007) Exochrome: structurally unique chromone dimer with antifungal and algicidal activity from Exophiala sp. Heterocycles 74:331–337

    CAS  Google Scholar 

  • Hutter JA, Salman M, Stavinoha WB et al (1996) Antiinflammatory C-glucosyl chromone from Aloe barbadensis. J Nat Prod 59:541–543

    PubMed  CAS  Google Scholar 

  • Ibrahim SRM (2010) New 2-(2-phenylethyl)chromone derivatives from the seeds of Cucumis melo L var. reticulatus. Nat Prod Commun 5:403–406

    PubMed  CAS  Google Scholar 

  • Ibrahim SRM (2014) New chromone and triglyceride from Cucumis melo seeds. Nat Prod Commun 9:205–208

    PubMed  CAS  Google Scholar 

  • Ingkaninan K, Ijzerman AP, Verpoorte R (2000) Luteolin, a compound with adenosine A1 receptor-binding activity, and chromone and dihydronaphthalenone constituents from Senna siamea. J Nat Prod 63:315–317

    PubMed  CAS  Google Scholar 

  • Ibrahim SRM, Mohamed GA (2015) Natural occurring 2-(2-phenylethyl) chromones, structure elucidation and biological activities. Nat Prod Res 29(16):1489–1520

    PubMed  CAS  Google Scholar 

  • Isaka M, Sappan M, Auncharoen PV (2010) Chromone derivatives from the wood-decay fungus Rhizina sp. BCC 12292. Phytochem Lett 3:152–155

    CAS  Google Scholar 

  • Isaka M, Haritakun R, Supothina S et al (2014) N-Hydroxypyridone alkaloids, chromone derivatives, and tetrahydroxanthones from the scale-insect pathogenic fungus Orbiocrella sp. BCC 33248. Tetrahedron 70:9198–9203

    CAS  Google Scholar 

  • Isaka M, Palasarn S, Choowong W et al (2019) Benzophenone and chromone derivatives and their dimers from the scale-insect pathogenic fungus Orbiocrella petchii BCC 51377. Tetrahedron 75:130646

    CAS  Google Scholar 

  • Ishar MPS, Singh G, Singh S et al (2006) Design, synthesis, and evaluation of novel 6-chloro-/fluorochromone derivatives as potential topoisomerase inhibitor anticancer agents. Bioorg Med Chem Lett 16:1366–1370

    PubMed  CAS  Google Scholar 

  • Ismail IS, Nagakura Y, Hirasawa Y et al (2009) Chrotacumines A–D, chromone alkaloids from Dysoxylum acutangulum. J Nat Prod 72:1879–1883

    PubMed  CAS  Google Scholar 

  • Itoh A, Tanahashi T, Nagakura N et al (2003) Two chromone-secoiridoid glycosides and three indole alkaloid glycosides from Neonauclea sessilifolia. Phytochemistry 62:359–369

    PubMed  CAS  Google Scholar 

  • Izwan MLM, Safinar II, Shaari K et al (2013) Chrotacumines e and F, two new chromone-alkaloid analogs from Dysoxylum acutangulum (Meliaceae) leaves. Chem Biodivers 10:1589–1596

    Google Scholar 

  • Jain SK, Meena S, Qazi AK et al (2013) Isolation and biological evaluation of chromone alkaloid dysoline, a new regioisomer of rohitukine from Dysoxylum binectariferum. Tetrahedron Lett 54:7140–7143

    CAS  Google Scholar 

  • Jiménez C, Marcos M, Villaverde MC et al (1989) A chromone from Zanthoxylum species. Phytochemistry 28:1992–1993

    Google Scholar 

  • Joshi BS, Ravindranath KR (1977) Isolation and identification of two phenolic ketones and a chromone from Dysophylla stellate Benth. J Chem Soc Perkin Trans 1:433–436

    Google Scholar 

  • Karlsson G, Rundcrantz H (1978) Peroral chromones: a new way to treat allergic rhinitis? Acta Otolaryngol 86:27–29

    Google Scholar 

  • Keri RS, Budagumpi S, Pai RK et al (2014) Chromones as a privileged scaffold in drug discovery: a review. Eur J Med Chem 78:340–374

    PubMed  CAS  Google Scholar 

  • Khadem S, Marles RJ (2012) Chromone and flavonoid alkaloids: occurrence and bioactivity. Molecules 17:191–206

    CAS  Google Scholar 

  • Khan MA, Nizami SS, Khan MNI et al (1995) New chromones from the roots of Mangifera indica. Fitoterapia 66:423–424

    CAS  Google Scholar 

  • Khan KM, Ambreen N, Hussain S et al (2009) Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors. Biorg Med Chem 17:2983–2988

    CAS  Google Scholar 

  • Khan A, Naz S, Farooq U et al (2018) Bioactive chromone constituents from Vitex negundo alleviate pain and inflammation. J Pain Res 11:95–102

    PubMed  CAS  Google Scholar 

  • Kim SB, Ahn JH, Han SB et al (2012) Anti-adipogenic chromone glycosides from Cnidium monnieri fruits in 3T3-L1 cells. Bioorg Med Chem Lett 22:6267–6271

    PubMed  CAS  Google Scholar 

  • Kimura Y, Sumiyoshi M, Taniguchi M et al (2008) Antitumor actions of a chromone glucoside cnidimoside A isolated from Cnidium japonicum. J Nat Med 62:308–313

    PubMed  CAS  Google Scholar 

  • Kito G, Kuriki H, Chiba S et al (1978) General pharmacology of 6-ethyl-3-(1H-tetrazol-5-yl)chromone (AA-344), a new orally effective anti-allergic agent. J Takeda Res Lab 37:202–227

    CAS  Google Scholar 

  • Kładna A, Berczyński P, Piechowska T et al (2014) Studies on the antioxidant activities of some new chromone compounds. Luminescence 29:846–853

    PubMed  Google Scholar 

  • Kumar R, Ilyas M, Parveen M (2006) Shafiullah. A new chromone from Cassia nodosa. J Asian Nat Prod Res 8:595–598

    PubMed  CAS  Google Scholar 

  • Kumar S, Singh BK, Pandey AK et al (2007) A chromone analog inhibits TNF-α induced expression of cell adhesion molecules on human endothelial cells via blocking NF-κB activation. Bioorg Med Chem 15:2952–2962

    PubMed  CAS  Google Scholar 

  • Kumara PM, Soujanya KN, Ravikanth G et al (2014) Rohitukine, a chromone alkaloid and a precursor of flavopiridol, is produced by endophytic fungi isolated from Dysoxylum binectariferum Hook.f and Amoora rohituka (Roxb). Wight & Arn. Phytomedicine 2:541–546

    Google Scholar 

  • Kuo YH, Lin BY (1999) A new dinorxanthane and chromone from the root of Tithonia diversifolia. Chem Pharm Bull 47:428–429

    CAS  Google Scholar 

  • Kuriki H, Saijo T, Ashida Y et al (1979) Effect of 6-ethyl-3-(1H-tetrazol-5-yl)chromone (AA-344) on the immediate and delayed hypersensitivity reactions. Jpn J Pharmacol 29:733–744

    PubMed  CAS  Google Scholar 

  • Kuroda M, Uchida S, Watanabe K et al (2009) Chromones from the tubers of Eranthis cilicica and their antioxidant activity. Phytochemistry 70:288–293

    PubMed  CAS  Google Scholar 

  • Langenhoven JH, Breytenbach JC, Gerritsma-Van Der Vijver LM et al (1988) An antihypertensive chromone from Ptaeroxylon obliquum. Planta Med 54:373

    PubMed  CAS  Google Scholar 

  • Larsen PO, Larsen FS (1979) Clinical trial of a new chromone compound for systemic treatment of atopic dermatitis. Acta Derm Venereol 59:270–271

    PubMed  CAS  Google Scholar 

  • Lei ZD, Liu DL, Zhao YM et al (2018) A new 2-(2-phenylethyl)chromone from Aquilaria sinensis. Chem Nat Compd 54:30–33

    CAS  Google Scholar 

  • Lemmich J (1995) Monoterpene, chromone and coumarin glucosides of Diplolophium buchananii. Phytochemistry 38:427–432

    CAS  Google Scholar 

  • Leonti M, Casu L, Solinas MN et al (2010) A chromone from Seseli praecox (Apiaceae). Nat Prod Commun 5:551–554

    PubMed  CAS  Google Scholar 

  • Lerdsirisuk P, Maicheen C, Ungwitayatorn J (2014) Antimalarial activity of HIV-1 protease inhibitor in chromone series. Bioorg Chem 57:142–147

    PubMed  CAS  Google Scholar 

  • Li X, Yu M, Meng D et al (2007) A new chromone glycoside from Polygonum capitatum. Fitoterapia 78:506–509

    PubMed  CAS  Google Scholar 

  • Li LM, Zou Q, Li GY (2010) Chromones from an ascomycete, Chaetomium aureus. Chin Chem Lett 21:1203–1205

    CAS  Google Scholar 

  • Li Y, Meng Y, Yang Y et al (2014) Chromones from the stems of Cassia fistula and their anti-tobacco mosaic virus activities. Phytochem Lett 10:46–49

    CAS  Google Scholar 

  • Li H, Tian JM, Tang HY et al (2015) Chaetosemins A–E, new chromones isolated from an Ascomycete Chaetomium seminudum and their biological activities. RSC Adv 5:29185–29192

    CAS  Google Scholar 

  • Liang H, Zhao YY, Zhang RY (1998) A new chromone glycoside from Bupleurum chinense. Chin Chem Lett 9:69–70

    CAS  Google Scholar 

  • Liao YY, Zhou GP, Wu GJ et al (2014) A new chromone glycoside from leaves of Salix matsudana. Chin Trad Herb Drugs 45:2887–2889

    CAS  Google Scholar 

  • Liao G, Dong WH, Yang JL et al (2018) Monitoring the chemical profile in agarwood formation within one year and speculating on the biosynthesis of 2-(2-phenylethyl)chromones. Molecules 23:1261

    PubMed Central  Google Scholar 

  • Lin W, Brauers G, Ebel R et al (2003) Novel chromone derivatives from the fungus Aspergillus versicolor isolated from the marine sponge Xestospongia exigua. J Nat Prod 66:57–61

    PubMed  CAS  Google Scholar 

  • Lin CL, Kao CL, Liu CM et al (2016) A new chromone from Citrus reticulata. Chem Nat Compd 52:789–790

    CAS  Google Scholar 

  • Liu J, Wu J, Zhao YX et al (2008) A new cytotoxic 2-(2-phenylethyl)chromone from Chinese eaglewood. Chin Chem Lett 19:934–936

    CAS  Google Scholar 

  • Liu L, Liu S, Niu S et al (2009) Isoprenylated chromone derivatives from the plant endophytic fungus Pestalotiopsis fici. J Nat Prod 72:1482–1486

    PubMed  CAS  Google Scholar 

  • Liu GB, Xu JL, Geng M et al (2010a) Synthesis of a novel series of diphenolic chromone derivatives as inhibitors of NO production in LPS-activated RAW264.7 macrophages. Bioorg Med Chem 18:2864–2871

    PubMed  CAS  Google Scholar 

  • Liu SZ, Feng JQ, Wu J et al (2010b) A new monoterpene-coumarin and a new monoterpene-chromone from Gerbera delavayi. Helv Chim Acta 93:2026–2029

    CAS  Google Scholar 

  • Liu H, Xu R, Feng L et al (2012) A novel chromone derivative with anti-inflammatory property via inhibition of ROS-dependent activation of TRAF6-ASK1-p38 pathway. PLoS ONE 7:e37168

    PubMed  PubMed Central  CAS  Google Scholar 

  • Liu X, Zhang BF, Yang L et al (2013) Two new chromones and a new flavone glycoside from Imperata cylindrical. Chin J Nat Med 11:77–80

    CAS  Google Scholar 

  • López JA, Barillas W, Gomez-Laurito J et al (1997) Granulosin, a new chromone from Galipea granulosa. J Nat Prod 60:24–26

    Google Scholar 

  • López-Martín J, Anam EM, Boira H et al (2002) Chromone and phenanthrene alkaloids from Dennettia tripetala. Chem Pharm Bull 50:1613–1615

    Google Scholar 

  • Lösgen S, Magull J, Schulz B et al (2008) Isofusidienols: novel chromone-3-oxepines produced by the endophytic fungus Chalara sp. Eur J Org Chem 2008:698–703

    Google Scholar 

  • Lu TS, Yi YH, Mao SL et al (2001) A new chromone glycosidé from Cassia siamea Lam. Chin Chem Lett 12:703–704

    CAS  Google Scholar 

  • Lu T, Deng S, Li C et al (2014) A new chromone from the twig of Mallotus apelta. Nat Prod Res 28:1864–1868

    PubMed  CAS  Google Scholar 

  • Lü TS, Yi YH, Yuan HY et al (2003) A new chromone glycoside from Cassia siamea Lam. Yaoxue Xuebao 38:113–115

    Google Scholar 

  • Luo Y, Qiu L, Deng Y et al (2018) A new chromone and a new aliphatic ester isolated from Daldinia eschscholtzii. J Asian Nat Prod Res 20:883–888

    PubMed  CAS  Google Scholar 

  • Lv L, Yang Q-Y, Zhao Y et al (2008) BACE1 (β-secretase) inhibitory chromone glycosides from Aloe vera and Aloe nobilis. Planta Med 74:540–545

    PubMed  CAS  Google Scholar 

  • Lynch B, Simon R, Roberts A (2011) In vitro and in vivo assessment of the genotoxic activity of aloesin. Regul Toxicol Pharmacol 61:215–221

    PubMed  CAS  Google Scholar 

  • Ma WG, Fuzzati N, Lu SL et al (1996) Further chromones from Eriosema tuberosum. Phytochemistry 43:1339–1343

    CAS  Google Scholar 

  • Ma LY, Wei F, Ma SC et al (2002) Two new chromone glycosides from Selaginella uncinata. Chin Chem Lett 13:748–751

    CAS  Google Scholar 

  • Ma LY, Ma SC, Wei F et al (2003) Uncinoside A and B, two new antiviral chromone glycosides from Selaginella uncinata. Chem Pharm Bull 51:1264–1267

    CAS  Google Scholar 

  • Machado NFL, Marques MPM (2010) Bioactive chromone derivatives-structural diversity. Curr Bioact Compd 6:76–89

    CAS  Google Scholar 

  • Mallick S, Dutta A, Ghosh J et al (2011) Protective therapy with novel chromone derivative against Leishmania donovani infection induces Th1 response in vivo. Chemotherapy 57:388–393

    PubMed  CAS  Google Scholar 

  • Mazzei M, Sottofattori E, Dondero R et al (1999) N,N-Dialkylaminosubstituted chromones and isoxazoles as potential anti-inflammatory agents. Farmaco 54:452–460

    PubMed  CAS  Google Scholar 

  • Mbah JA, Tchuendem MHK, Tane P et al (2002) Two chromones from Peperomia vulcanica. Phytochemistry 60:799–801

    PubMed  CAS  Google Scholar 

  • Meng H, Li G, Huang J, Zhang K et al (2013) Sesquiterpene coumarin and sesquiterpene chromone derivatives from Ferula ferulaeoides (Steud.) Korov. Fitoterapia 86:70–77

    PubMed  CAS  Google Scholar 

  • Meng LH, Chen HQ, Form I et al (2016) New chromone, isocoumarin, and indole alkaloid derivatives from three sponge-derived fungal strains. Nat Prod Commun 11:1293–1296

    PubMed  Google Scholar 

  • Mohamed YMA, Vik A, Hofer T et al (2013) Polyunsaturated fatty acid-derived chromones exhibiting potent antioxidant activity. Chem Phys Lipids 170–171:41–45

    PubMed  Google Scholar 

  • Morita H, Nugroho AE, Nagakura Y et al (2014) Chrotacumines G–J, chromone alkaloids from Dysoxylum acutangulum with osteoclast differentiation inhibitory activity. Bioorg Med Chem Lett 24:2437–2439

    PubMed  CAS  Google Scholar 

  • Motai T, Kitanaka S (2005) Sesquiterpene chromones from Ferula fukanensis and their nitric oxide production inhibitory effects. J Nat Prod 68:1732–1735

    PubMed  CAS  Google Scholar 

  • Nadmid S, Plaza A, Garcia R et al (2015) Cystochromones, unusual chromone-containing polyketides from the myxobacterium Cystobacter sp. MCy9104. J Nat Prod 78:2023–2028

    PubMed  CAS  Google Scholar 

  • Nedialkov PT, Kitanov GM (2002) Two benzophenone O-arabinosides and a chromone from Hypericum annulatum. Phytochemistry 59:867–871

    PubMed  CAS  Google Scholar 

  • Negishi H, Maoka T, Njelekela M et al (2011) New chromone derivative terminalianone from African plant Terminalia brownii Fresen (Combretaceae) in Tanzania. J Asian Nat Prod Res 13:281–283

    PubMed  CAS  Google Scholar 

  • North BJ, Marshall BL, Borra MT et al (2003) The human Sir2 ortholog, SIRT2, is an NAD + -dependent tubulin deacetylase. Mol Cell 11:437–444

    PubMed  CAS  Google Scholar 

  • Okamura N, Hine N, Tateyama Y et al (1998) Five chromones from Aloe vera leaves. Phytochemistry 49:219–223

    CAS  Google Scholar 

  • Opretzka LCF, Espírito-Santo RF, Nascimento OA et al (2019) Natural chromones as potential anti-inflammatory agents: pharmacological properties and related mechanisms. Int Immunopharmacol 72:31–39

    PubMed  CAS  Google Scholar 

  • Panche AN, Diwan AD, Chandra SR (2016) Flavonoids: an overview. J Nutr Sci 5:e47

    PubMed  PubMed Central  CAS  Google Scholar 

  • Park YJ, Kim HJ, Lee SJ et al (2007) A new chromone, 11-hydroxy-sec-O-glucosylhamaudol from Ostericum koreanum. Chem Pharm Bull 55:1065–1066

    CAS  Google Scholar 

  • Payard M, Mouysset G, Tronche P et al (1985) Research of antiallergic agents: 2-hydroxymethylchromone and structural analogs. Eur J Med Chem 20:117–120

    CAS  Google Scholar 

  • Payen L, Honorat M, Guitton J et al (2014) MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts. Oncotarget 5:11957–11970

    PubMed  Google Scholar 

  • Peng B, Gao ZP, He W et al (2014) A new chromone glycoside from Dryopteris fragrans (II). Chin Trad Herb Drugs 45:2136–2138

    CAS  Google Scholar 

  • Phosrithong N, Samee W, Nunthanavanit P et al (2012) In vitro antioxidant activity study of novel chromone derivatives. Chem Biol Drug Des 79:981–989

    PubMed  CAS  Google Scholar 

  • Ramani VA, Jagajeevanram P, Kalaiselvi (2003) Extraction and characterization of chromone from Alangium salvifolium. Asian J Chem 15:1693–1698

    CAS  Google Scholar 

  • Rattanaburi S, Mahabusarakam W, Phongpaichit S et al (2013) A new chromone from the leaves of Melaleuca cajuputi Powell. Nat Prod Res 27:221–225

    PubMed  CAS  Google Scholar 

  • Recanatini M, Bisi A, Cavalli A et al (2001) A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17α-hydroxylase/C17,20-lyase. J Med Chem 44:672–680

    PubMed  CAS  Google Scholar 

  • Reynolds JEF (1993) Martindale—the extra pharmacopoeia, 30th edn. The Pharmaceutical Press, London, p 1024

    Google Scholar 

  • Robeson DJ, Ingham JL, Harborne JB (1980) Identification of two chromone phytoalexins in the sweet pea, Lathyrus odoratus. Phytochemistry 19:2171–2173

    CAS  Google Scholar 

  • Rukachaisirikul V, Chantaruk S, Pongcharoen W et al (2006) Chromone derivatives from the filamentous fungus Lachnum sp. BCC 2424. J Nat Prod 69:980–982

    PubMed  CAS  Google Scholar 

  • Safia Kamil M, Jadiya P et al (2015) The chromone alkaloid, rohitukine, affords anti-cancer activity via modulating apoptosis pathways in A549 cell line and yeast mitogen activated protein kinase (MAPK) pathway. PLoS ONE 10:e0137991

    PubMed  PubMed Central  CAS  Google Scholar 

  • Saijo T, Ashida Y, Kuriki H et al (1979) Inhibitory action of 6-ethyl-3-(1H-tetrazol-5-yl)chromone (AA-344) on IgE-, IgGa- or chemical agent-induced histamine release from isolated rat mast cells. Jpn J Pharmacol 29:531–540

    PubMed  CAS  Google Scholar 

  • Satake T, Kamiya K, Saiki Y et al (1999) Chromone C-glycosides from Baeckea frutescens. Phytochemistry 50:303–306

    CAS  Google Scholar 

  • Savina AA, Perel’son ME, Ban’kovskii AI et al (1970) The structure of seselirin: a new chromone from the roots of Seseli sessiliflorum. Chem Nat Compd 6:419–422

    Google Scholar 

  • Schepetkin IA, Kirpotina LN, Khlebnikov AI et al (2014) Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones. Biochem Pharmacol 92:627–641

    PubMed  PubMed Central  CAS  Google Scholar 

  • Seifert T, Malo M, Kokkola T et al (2014) Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells. J Med Chem 57:9870–9888

    PubMed  CAS  Google Scholar 

  • Shah A, Bloomquist E, Tang S et al (2018) FDA approval: ribociclib for the treatment of postmenopausal women with hormone receptor-positive, HER2-negative advanced or metastatic breast cancer. Clin Cancer Res 24:2999–3004

    PubMed  CAS  Google Scholar 

  • Shang ZP, Meng JJ, Zhao QC et al (2013) Two new chromone glycosides from Drynaria fortune. Fitoterapia 84:130–134

    PubMed  CAS  Google Scholar 

  • Sharma VP, Kumar P (2014) Synthesis, spectral studies and antibacterial activity of 3-(4-phenyl-2,3-dihydro-1,5-benzodiazepin-2-yl)chromone. Asian J Chem 26:3992–3994

    CAS  Google Scholar 

  • Shaw AY, Chang CY, Liau HH et al (2009) Synthesis of 2-styrylchromones as a novel class of antiproliferative agents targeting carcinoma cells. Eur J Med Chem 44:2552–2562

    PubMed  CAS  Google Scholar 

  • Shen YX, Teng HL, Yang GZ et al (2010) A new chromone derivative from Berchemia lineata. Yaoxue Xuebao 45:1139–1143

    CAS  Google Scholar 

  • Shohai T, Shafique M, Dhanya N et al (2011) Importance of flavonoides in therapeutics. Hygeia J Drugs Med 3:1–18

    Google Scholar 

  • Silva CFM, Batista VF, Pinto DCGA et al (2018) Challenges with chromone as a privileged scaffold in drug discovery. Expert Opin Drug Discov 13:795–798

    PubMed  CAS  Google Scholar 

  • Simon A, Chulia AJ, Kaouadji M et al (1994) Quercetin 3-[triacetylarabinosyl(1 → 6)galactoside] and chromones from Calluna vulgaris. Phytochemistry 36:1043–1045

    PubMed  CAS  Google Scholar 

  • Singh J (1982) Two chromone glycosides from Cassia multijuga. Phytochemistry 21:1177–1179

    CAS  Google Scholar 

  • Singh BN, Vaughan Williams EM (1970) The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol 39:657–667

    PubMed  PubMed Central  CAS  Google Scholar 

  • Siriwach R, Kinoshita H, Kitani S et al (2012) Mycoleptione, a new chromone derivative isolated from the endophytic fungus Mycoleptodiscus sp. MU41. J Antibiot 65:627–629

    CAS  Google Scholar 

  • Steck W (1973) Coumarins and chromones from Lomatium macrocarpum. Phytochemistry 12:2283–2286

    Google Scholar 

  • Su BN, Takaishi Y, Honda G et al (2000) Sesquiterpene phenylpropanoid and sesquiterpene chromone derivatives from Ferula pallida. J Nat Prod 63:520–522

    PubMed  CAS  Google Scholar 

  • Sumiyoshi M, Kimura Y (2010) Enhancing effects of a chromone glycoside, eucryphin, isolated from Astilbe rhizomes on burn wound repair and its mechanism. Phytomedicine 17:820–829

    PubMed  CAS  Google Scholar 

  • Sun YW, Liu GM, Huang H et al (2012) Chromone derivatives from Halenia elliptica and their anti-HBV activities. Phytochemistry 75:169–176

    PubMed  CAS  Google Scholar 

  • Sun YL, Bao J, Liu KS et al (2013) Cytotoxic dihydrothiophene-condensed chromones from the marine-derived fungus Penicillium oxalicum. Planta Med 79:1474–1479

    PubMed  CAS  Google Scholar 

  • Suwanborirux K, Chang CJ, Cassady JM (1987) Novel chromones from Spathelia sorbifolia. J Nat Prod 50:102–107

    PubMed  CAS  Google Scholar 

  • Tanaka N, Kashiwada Y, Nakano T et al (2009) Chromone and chromanone glucosides from Hypericum sikokumontanum and their anti-Helicobacter pylori activities. Phytochemistry 70:141–146

    PubMed  CAS  Google Scholar 

  • Tane P, Ayafor JF, Luc Sondengam B et al (1990) Chromone glycosides from Schumanniophyton magnificum. Phytochemistry 2:1004–1007

    Google Scholar 

  • Tschesche R, Delhvi S, Sepulveda S et al (1979) Eucryphin, a new chromone rhamnoside from the bark of Eucryphia cordifolia. Phytochemistry 18:867–869

    CAS  Google Scholar 

  • Tuntiwachwuttikul P, Phansa P, Pootaeng-on Y et al (2006) Chromones from the branches of Harrisonia perforate. Chem Pharm Bull 54:44–47

    CAS  Google Scholar 

  • Van Heerden FR, Van Wyk BE, Viljoen AM (1996) Aloeresins E and F, two chromone derivatives from Aloe peglerae. Phytochemistry 43:867–869

    Google Scholar 

  • Vasconcelos JMJ, Silva AMS, Cavaleiro JAS (1998) Chromones and flavanones from Artemisia campestris subsp. maritima. Phytochemistry 49:1421–1424

    CAS  Google Scholar 

  • Wang T, Li LF, Zhang K et al (2001) New 2-(2-Phenylethyl) chromones from Bothriochloa ischaemum. J Asian Nat Prod Res 3:145–149

    PubMed  CAS  Google Scholar 

  • Wang YB, Huang R, Zhang HB et al (2006) Chromone glycosides from Knoxia corymbosa. J Asian Nat Prod Res 8:663–670

    PubMed  CAS  Google Scholar 

  • Wang TY, Li Q, Bi KS (2018) Bioactive flavonoids in medicinal plants: structure, activity and biological fate. Asian J Pharm Sci 13:12–23

    PubMed  Google Scholar 

  • Willerson JT, Ridker PM (2004) Inflammation as a cardiovascular risk factor. Circulation 109(21 Suppl 1)::II2‐II10

    Google Scholar 

  • Wu QL, Liao YH, Wang SP et al (1997) New chromone glycosides from Hypericum japonicum. Chin Chem Lett 8:41–42

    CAS  Google Scholar 

  • Wu QL, Wang SP, Du LJ et al (1998) Chromone glycosides and flavonoids from Hypericum japonicum. Phytochemistry 49:1417–1420

    CAS  Google Scholar 

  • Wu MC, Peng CF, Chen IS et al (2001) Antitubercular chromones and flavonoids from Pisonia aculeate. J Nat Prod 74:976–982

    Google Scholar 

  • Wu D, Zhang M, Zhang C et al (2008) Chromones from the flower buds of Tussilago farfara. Biochem Syst Ecol 36:219–222

    CAS  Google Scholar 

  • Xia MW, Cui CB, Li CW et al (2015) Rare chromones from a fungal mutant of the marine-derived Penicillium purpurogenum G59. Mar Drugs 13:5219–5236

    PubMed  PubMed Central  CAS  Google Scholar 

  • Xia LL, Li W, Wang H et al (2019) One new 2-(2-phenylethyl)chromone Derivative from agarwood of Aquilaria crassna in Cambodia. Phytochem Lett 31:69–72

    CAS  Google Scholar 

  • Xu J, Kjer J, Sendker J et al (2009) Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata. J Nat Prod 72:662–665

    PubMed  CAS  Google Scholar 

  • Xue BY, Li W, Li L et al (2000) A pharmacodynamic research on chromone glucosides of fangfeng. Chin J Chin Mat Med 25:297–299

    CAS  Google Scholar 

  • Yadav P, Parshad B, Manchanda P et al (2014) Chromones and their derivatives as radical scavengers: a remedy for cell impairment. Curr Top Med Chem 14:2552–2575

    PubMed  CAS  Google Scholar 

  • Yagura T, Ito M, Kiuchi F et al (2003) Four new 2-(2-phenylethyl)chromone derivatives from withered wood of Aquilaria sinensis. Chem Pharm Bull 51:560–564

    CAS  Google Scholar 

  • Yang JS, Wang YL, Su YL (1990) Studies on the chemical constituents of Aquilaria sinensis (Lour.) Gilg. V. Isolation and characterization of three 2-(2-phenylethyl) chromone derivatives. Acta Pharm Sin 25:186–190

    CAS  Google Scholar 

  • Yang L, Qiao L, Xie D et al (2012a) 2-(2-Phenylethyl)chromones from Chinese eaglewood. Phytochemistry 76:92–97

    PubMed  CAS  Google Scholar 

  • Yang SJ, Yao QQ, Li YN et al (2012b) A new chromone from Angelica polymorpha with cytotoxic activity. J Asian Nat Prod Res 14:76–79

    PubMed  CAS  Google Scholar 

  • Yang L, Mei WL, Zeng YB et al (2013a) 2-(2-Phenylethyl)chromone derivatives in Chinese agarwood “Qi-Nan” from Aquilaria sinensis. Planta Med 79:1329–1334

    PubMed  CAS  Google Scholar 

  • Yang L, Yao J, Shu L et al (2013b) Chromones from the flowers of Rosa rugosa and their cytotoxicity. Asian J Chem 25:8355–8357

    CAS  Google Scholar 

  • Yang DL, Wang H, Guo ZK et al (2014a) A new 2-(2-phenylethyl)chromone derivative in Chinese agarwood Qi-Nan from Aquilaria sinensis. J Asian Nat Prod Res 16:770–776

    PubMed  CAS  Google Scholar 

  • Yang G, Zhao W, Zhang T et al (2014b) Chromone derivatives from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activities. Heterocycles 89:183–188

    CAS  Google Scholar 

  • Yoon JS, Lee MK, Sung SH et al (2006) Neuroprotective 2-(2-phenylethyl)chromones of Imperata cylindrical. J Nat Prod 69:290–291

    PubMed  CAS  Google Scholar 

  • Yoshimitsu H, Nishida M, Hashimoto F et al (2007) Chromone and flavonol glycosides from Delphinium hybridum cv. “Belladonna Casablanca”. J Nat Med 61:334–338

    CAS  Google Scholar 

  • Youssef DTA, Ramadan MA, Khalifa AA (1998) Acetophenones, a chalcone, a chromone and flavonoids from Pancratium maritimum. Phytochemistry 49:2579–2583

    CAS  Google Scholar 

  • Yu D, Chen C-H, Brossi A et al (2004) Anti-AIDS agents. 60. Substituted 3′R,4′R-di-O-(-)-camphanoyl- 2′,2′-dimethyldihydropyrano[2,3-f]chromone (DCP) analogues as potent anti-HIV agents. J Med Chem 47:4072–4082

    PubMed  CAS  Google Scholar 

  • Yu J, Song X, Wang D et al (2017) Five new chromone glycosides from Scindapsus officinalis (Roxb.) Schott. Fitoterapia 122:101–106

    PubMed  CAS  Google Scholar 

  • Yuan L, Huang W, Gao Y et al (2014) A new chromone from the stems of Cassia fistula and its anti-tobacco mosaic virus activity. Asian J Chem 26:8253–8254

    Google Scholar 

  • Zhang Y, Chen Y (1997) Isobiflorin, a chromone C-glucoside from cloves (Eugenia caryophyllata). Phytochemistry 45:401–403

    CAS  Google Scholar 

  • Zhang F, Li L, Niu S, Si Y et al (2012) A thiopyranchromenone and other chromone derivatives from an endolichenic fungus, Preussia Africana. J Nat Prod 75:230–237

    PubMed  CAS  Google Scholar 

  • Zhao YM, Qi HY, Shi YP (2010) Several chromones from the stems of Polygonum aubertii Henry. J Asian Nat Prod Res 12:623–628

    PubMed  CAS  Google Scholar 

  • Zhao J, Zhou M, Liu Y et al (2011) Chromones and coumarins from the dried fructus of Cnidium monnieri. Fitoterapia 82:767–771

    PubMed  CAS  Google Scholar 

  • Zhao YM, Yang L, Dong WH et al (2019) Three new 2-(2-phenylethyl)chromone derivatives from agarwood of Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae) in Laos. Phytochem Lett 32:134–137

    CAS  Google Scholar 

  • Zou Z, Xu P, Wu C et al (2016) Carboxymethyl flavonoids and a chromone with antimicrobial activity from Selaginella moellendorffii Hieron. Fitoterapia 111:124–129

    PubMed  CAS  Google Scholar 

Download references

Acknowledgements

This work was financially supported by the National Research Foundation of South Africa and the South African Medical Research Council (SAMRC).

Author information

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Faculty of Science, Tshwane University of Technology, Pretoria, 0001, South Africa

    Ruchi Badoni Semwal, Deepak Kumar Semwal, Sandra Combrinck & Alvaro Viljoen

  2. Department of Chemistry, Pt. Lalit Mohan Sharma Govt. Post Graduate College, Rishikesh, 249201, India

    Ruchi Badoni Semwal

  3. Department of Phytochemistry, Faculty of Biomedical Sciences, Uttarakhand Ayurved University, Harrawala, Dehradun, 248001, India

    Deepak Kumar Semwal

  4. SAMRC Herbal Drugs Research Unit, Tshwane University of Technology, Pretoria, 0001, South Africa

    Alvaro Viljoen

Authors
  1. Ruchi Badoni Semwal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Deepak Kumar Semwal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sandra Combrinck
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alvaro Viljoen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alvaro Viljoen.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Semwal, R.B., Semwal, D.K., Combrinck, S. et al. Health benefits of chromones: common ingredients of our daily diet. Phytochem Rev 19, 761–785 (2020). https://doi.org/10.1007/s11101-020-09681-w

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11101-020-09681-w

Keywords

Search

Navigation