Abstract
Severe skin wounds cause great problems and sufferings to patients. In this study, an injectable wound dressing based on strontium ion cross-linked starch hydrogel (SSH) was developed and evaluated. The good inject-ability of SSH made it easy to be delivered onto the wound surface. The good tissue adhesiveness of SSH ensured a firm protection of the wound. Besides, SSH supported the proliferation of NIH/3T3 fibroblasts and facilitated the migration of human umbilical vein endothelial cells (HUVECs). Importantly, SSH exhibited strong antibacterial effects on Staphylococcus aureus (S. aureus), which could prevent wound infection. These results demonstrate that SSH is a promising wound dressing material for promoting wound healing.
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Acknowledgements
This work was sponsored by the National Natural Science Foundation of China (Grant Nos. 51672184, 81930070, 81622032 and 81501858), the Natural Science Research of Jiangsu Higher Education Institutions (No. 17KJA180011), the Jiangsu Innovation and Entrepreneurship Program, and the Priority Academic Program Development of Jiangsu High Education Institutions (PAPD).
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Mao, Y., Pan, M., Yang, H. et al. Injectable hydrogel wound dressing based on strontium ion cross-linked starch. Front. Mater. Sci. 14, 232–241 (2020). https://doi.org/10.1007/s11706-020-0508-6
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DOI: https://doi.org/10.1007/s11706-020-0508-6