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Synthesis and radiolabeling of vitamin C-stabilized selenium nanoparticles as a promising approach in diagnosis of solid tumors

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Abstract

This study aimed to develop a simple method for synthesis of vitamin c-coated selenium nanoparticles which were then labeled with technetium-99m for further in vivo studies on normal and solid tumor induced mice. Results showed the formation of amorphous SeNPs with a mean size of (23 ± 5 nm). The radiolabelling yield of [99mTc-Vit_C (SeNPs)] was (96 ± 2%) with stability up to 6 h. Effective target non-target ratios were obtained in solid tumor-induced mice throughout the experimental time points. [99mTc-Vit_C (SeNPs)] complex showed promising features which make it a potential radiopharmaceutical for imaging of solid tumors.

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Authors and Affiliations

  1. Labeled Compounds Department, Hot Labs Center, Atomic Energy Authority, Cairo, Egypt

    Mohamed Korany & Samia M. Ayoub

  2. Biochemistry Department, Faculty of Science, Beni Suef University, Beni Suef, Egypt

    Basant Mahmoud & Sayed A. Ahmed

  3. Radioactive Isotopes and Generators Department, Hot Labs Center, Atomic Energy Authority, Cairo, Egypt

    Tamer M. Sakr

  4. Bani Sweif Technological University (BST), Beni Suef, Egypt

    Sayed A. Ahmed

Authors
  1. Mohamed Korany
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  2. Basant Mahmoud
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  3. Samia M. Ayoub
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  4. Tamer M. Sakr
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  5. Sayed A. Ahmed
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Correspondence to Mohamed Korany or Tamer M. Sakr.

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Korany, M., Mahmoud, B., Ayoub, S.M. et al. Synthesis and radiolabeling of vitamin C-stabilized selenium nanoparticles as a promising approach in diagnosis of solid tumors. J Radioanal Nucl Chem 325, 237–244 (2020). https://doi.org/10.1007/s10967-020-07195-5

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  • DOI: https://doi.org/10.1007/s10967-020-07195-5

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