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Human Deoxyribonuclease (rhDNase) Nebulization as an Alternative Treatment for Refractory Plastic Bronchitis After Fontan Surgery

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Abstract

We report the case of a 5-year-old boy who developed chronic plastic bronchitis after Fontan surgery for a complex congenital heart disease. During a new admission for acute exacerbation of plastic bronchitis, he started on a mucolytic treatment with inhaled rhDNAse instead of inhaled fibrinolytics because of the potential bleeding risk in a patient on combined coumarin and aspirin treatment. Respiratory symptoms resolved promptly, and the patient was discharged home on rhDNAse treatment. He remained clinically stable on rhDNAse treatment without further hospitalization until definitive treatment with dynamic lymphangiography and percutaneous embolization.

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Authors and Affiliations

  1. Division of Neonatal and Pediatric Intensive Care, Department of Pediatrics, Obstetrics and Gynecology, Geneva University Hospitals, Geneva, Switzerland

    Serge Grazioli

  2. Division of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland

    Anne-Laure Rougemont

  3. Pediatric Pulmonology Unit, Department of Pediatrics, Obstetrics and Gynecology, Geneva University Hospitals, Geneva, Switzerland

    Isabelle Ruchonnet-Métrailler

Authors
  1. Serge Grazioli
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  2. Anne-Laure Rougemont
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  3. Isabelle Ruchonnet-Métrailler
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Corresponding author

Correspondence to Serge Grazioli.

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All the authors declare no conflict of interest and no relationship with industry. All the authors disclose any prior presentation of study as an abstract or poster.

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This is a case report with no personally identifiable information included in the report.

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Informed consent was obtained from the patient’s legal guardians.

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Grazioli, S., Rougemont, AL. & Ruchonnet-Métrailler, I. Human Deoxyribonuclease (rhDNase) Nebulization as an Alternative Treatment for Refractory Plastic Bronchitis After Fontan Surgery. Pediatr Cardiol 41, 1071–1073 (2020). https://doi.org/10.1007/s00246-020-02368-1

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  • DOI: https://doi.org/10.1007/s00246-020-02368-1

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