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Antibiotic Uptake by Plant Model

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Abstract

A model for predicting the uptake of tetracycline and amoxicillin by vegetable plants using STELLA® was developed. Simulations were performed for a 30-day period during which lettuce and carrot were irrigated with the two antibiotics of known concentrations. The model predicts antibiotic concentrations in several compartments, including porewater, soil, and plant tissues. Simulations showed that the number of antibiotics found in soil fraction was larger than the amount in plant tissues. The developed model for tetracycline uptake by carrot gave a chi-square (χ2) value of 0.2 and by lettuce recorded a χ2 value of 0.6. The model was considered efficient based on the χ2 values. Validation of the antibiotic’s uptake model showed an appreciable agreement between simulated and measured experimental data with deviation expressed as percentage being 2.6% for tetracycline uptake by carrot model and 37.9% for tetracycline uptake by lettuce model. Leaching and evaporation processes of antibiotics were found from the sensitivity analysis of the model to be the most important processes influencing the uptake model. These processes could be determined accurately and hence makes the model easily adoptive for other antibiotics. Further antibiotic uptake studies should focus on the physical-chemical properties of the antibiotics and abiotic environmental condition effect on the uptake model developed.

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Acknowledgements

The project was funded by DANIDA, the Ministry of Foreign Affairs of Denmark, under the Safe Water for Food (SaWaFo); grant number 11-058DHI. We gratefully acknowledge Prof. Stefan Trapp of the Department of Environmental Science and Engineering, Technical University of Denmark, Denmark, for providing valuable input to the study.

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Authors and Affiliations

  1. Department of Laboratory Technology, Kumasi Technical University, Kumasi, Ghana

    David Azanu

  2. Toxicology Laboratory, Analytical Biosciences, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

    Sven Erik Jørgensen & Bjarne Styrishave

  3. Department of Chemistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

    Godfred Darko

  4. Department of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

    Robert Clement Abaidoo

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  1. David Azanu
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  2. Sven Erik Jørgensen
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Correspondence to David Azanu.

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Azanu, D., Jørgensen, S.E., Darko, G. et al. Antibiotic Uptake by Plant Model. Environ Model Assess 25, 545–553 (2020). https://doi.org/10.1007/s10666-020-09712-y

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