Abstract
COVID-19 is a respiratory disease. A recent report in Lancet examined, retrospectively, 137 patients with COVD-19. Patients that died had elevated IL-6 levels and acute respiratory distress syndrome. These data have obvious implications for how to control mortality in COVID-19.
Similar content being viewed by others
Effective drugs that block and reverse lung fibrosis have not been identified. That COVID-19 is a respiratory disease is without question. A recent paper published in Lancet (Zhou et al. 2020) performed a retrospective study on patients at two hospitals in Wuhan, China. This paper was extremely data rich, but several points that were not adequately emphasized in this manuscript are of critical importance.
COVID-19 patients developed acute respiratory distress syndrome (ARDS), a disease that is characterized by rapid onset fibrosis. In this study, of 191 confirmed coronavirus patients, 50/54 patients that died had developed ARDS; conversely, only 9/137 survivors had ARDS. Moreover, the authors reported that chronic obstructive pulmonary disease (COPD) was cormorbid with COVID-19 (p = 0.056). Levels of interleukin (IL)-6, a proinflammatory cytokine linked with connective tissue disorders including fibrosis, were significantly higher in patients who died, and appeared to increase with disease progression. In survivors, essentially no alterations in IL-6 levels were observed.
These data strongly imply that not only is pulmonary fibrosis a comorbidity for COVID-19, but that it may be the cause of mortality for COVID-19. It also suggests that it may be reasonable to explore if IL-6 antagonists may be useful to treat COVID-19. In any event, these data strongly support the contention that development of anti-fibrotic agents is imperative not only to affect diseases such as scleroderma, idiopathic pulmonary fibrosis, Duchenne’s muscular dystrophy and metastatic cancers, but is also necessary to treat COVID-19.
Reference
Zhou F, Yu T, Du R et al (2020) Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395:1054–1062
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
