Skip to main content
Log in

The Single Nucleotide Polymorphisms of Chromosome 9p21 and CD147 Were Relevant with the Carotid Plaque Risk in Acute Cerebral Infarction Patients Among Chinese Han Population

  • Published:
Journal of Molecular Neuroscience Aims and scope Submit manuscript

Abstract

This study focused on the relevance between the carotid plaque formation and the single nucleotide polymorphisms of chromosome 9p21 and CD147 in acute non-cardiogenic cerebral infarction. A total of 937 eligible patients were enrolled and categorized into carotid plaque group or non-carotid plaque group. The baseline data was analyzed, and the SNPs of chromosome 9p21 and CD147 were detected. After analyzing the results of clinic data and SNPs, we found that age, total cholesterol, low density lipoprotein, systolic blood pressure, fasting serum glucose, and NIHSS score are associated with plaque formation. Meanwhile, rs10757274, rs4977574, and rs4919862 existed statistical differences between two groups. We also analyzed linkage disequilibrium, haplotype, and inheritance models of these three SNPs, and drew the ROC curve to assess diagnostic efficiency. The results showed that mutations of SNP rs10757274 and rs4977574 in chromosome 9p21 together with SNP rs4919862 located in gene CD147 were highly relevant with the carotid plague formation in acute cerebral ischemia patients. Compared with single SNP genotype mutation, combined allele mutations on rs10757274 or rs4977574 in chromosome 9p21 with rs4919862 in CD147 resulted in much higher risks of patients, which might be associated with acute cerebral infarction happening.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  • Bi J, Yang L, Liu D, Wu J, Tong X, Cen S, Zhou D, Zhang T, Yi L (2015) Sequence variants on chromosome 9p21 are associated with ischemic stroke and the lipids level in Chinese Han population. J Stroke Cerebrovasc Dis 24(4):894–900

    Article  Google Scholar 

  • Cunnington MS, Santibanez Koref M, Mayosi BM, Burn J, Keavney B (2010) Chromosome 9p21 SNPs associated with multiple disease phenotypes correlate with ANRIL expression. PLoS Genet 6(4):e1000899

    Article  Google Scholar 

  • Fornage M, Doris PA (2005) Single-nucleotide polymorphism genotyping for disease association studies. Methods Mol Med 108:159–172

    CAS  PubMed  Google Scholar 

  • Jin R, Xiao AY, Chen R, Granger DN, Li G (2017) Inhibition of CD147 (cluster of differentiation 147) ameliorates acute ischemic stroke in mice by reducing thromboinflammation. Stroke 48(12):3356–3365

    Article  CAS  Google Scholar 

  • Kaur H, Prakash A, Medhi B (2013) Drug therapy in stroke: from preclinical to clinical studies. Pharmacology 92(5–6):324–334

    Article  CAS  Google Scholar 

  • Khoshnam SE, Winlow W, Farzaneh M, Farbood Y, Moghaddam HF (2017) Pathogenic mechanisms following ischemic stroke. Neurol Sci 38(7):1167–1186

    Article  Google Scholar 

  • Kim AS et al (2015) Global Stroke Belt: geographic variation in stroke burden worldwide. Stroke 46(12):3564–3570

    Article  Google Scholar 

  • Lu Z et al (2015) Variants on chromosome 9p21 confer risks of noncardioembolic cerebral infarction and carotid plaque in the Chinese Han population. J Atheroscler Thromb 22(10):1061–1070

    Article  CAS  Google Scholar 

  • McPherson R et al (2007) A common allele on chromosome 9 associated with coronary heart disease. Science 316(5830):1488–1491

    Article  CAS  Google Scholar 

  • Meens MJ et al (2012) Risky communication in atherosclerosis and thrombus formation. Swiss Med Wkly 142:w13553

    PubMed  Google Scholar 

  • Ni X, Zhang J (2014) Association between 9p21 genomic markers and ischemic stroke risk: evidence based on 21 studies. PLoS One 9(3):e90255

    Article  Google Scholar 

  • Ni T, Chen M, Yang K, Shao J, Fu Y, Zhou W (2017) Association of CD147 genetic polymorphisms with carotid atherosclerotic plaques in a Han Chinese population with cerebral infarction. Thromb Res 156:29–35

    Article  CAS  Google Scholar 

  • Picher AJ, Hernández F, Budeus B, Soriano E, Avila J (2018) Human brain single nucleotide polymorphism: validation of DNA sequencing. J Alzheimers Dis Rep 2(1):103–109

    Article  Google Scholar 

  • Pott J, Burkhardt R, Beutner F, Horn K, Teren A, Kirsten H, Holdt LM, Schuler G, Teupser D, Loeffler M, Thiery J, Scholz M (2017) Genome-wide meta-analysis identifies novel loci of plaque burden in carotid artery. Atherosclerosis 259:32–40

    Article  CAS  Google Scholar 

  • Ritz K et al (2014) Cause and mechanisms of intracranial atherosclerosis. Circulation 130(16):1407–1414

    Article  Google Scholar 

  • Su H, Yang Y (2018) The roles of CyPA and CD147 in cardiac remodelling. Exp Mol Pathol 104(3):222–226

    Article  CAS  Google Scholar 

  • Sun H, Zou X, Liu L (2013) Epidemiological factors of stroke: a survey of the current status in China. J Stroke 15(2):109–114

    Article  Google Scholar 

  • Sutherland BA et al (2012) Neuroprotection for ischaemic stroke: translation from the bench to the bedside. Int J Stroke 7(5):407–418

    Article  Google Scholar 

  • von Ungern-SternbergSNI, et al. (2018). "Extracellular matrix metalloproteinase inducer EMMPRIN (CD147) in cardiovascular disease." Int J Mol Sci 19(2)

  • Xu B et al (2018) Study of serum CD147 level in patients with transient ischemic attack and CD147 expression in atherosclerotic plaque. J Cardiovasc Transl Res 11(4):285–291

    Article  Google Scholar 

  • Yue X, Tian L, Fan X, Xu G, Shi FD, Liu X (2015) Chromosome 9p21.3 variants are associated with cerebral infarction in Chinese population. J Mol Neurosci 56(3):546–552

    Article  CAS  Google Scholar 

  • Zhang W et al (2012) Variants on chromosome 9p21.3 correlated with ANRIL expression contribute to stroke risk and recurrence in a large prospective stroke population. Stroke 43(1):14–21

    Article  Google Scholar 

  • Zhou J, Song B, Duan X, Long Y, Lu J, Li Z, Zeng S, Zhan Q, Yuan M, Yang Q, Xia J (2014) Association of BSG genetic polymorphisms with atherosclerotic cerebral infarction in the Han Chinese population. Int J Neurosci 124(10):734–740

    Article  CAS  Google Scholar 

Download references

Funding

This work was sponsored by the National Nature Science Foundation of China (81771281).

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Yulan Feng or Yi Fu.

Ethics declarations

This study was approved by the Ethics Committee of Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine.

Conflict of Interest

The authors declare that they have no conflicts of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jin, W., Wu, W., Yang, K. et al. The Single Nucleotide Polymorphisms of Chromosome 9p21 and CD147 Were Relevant with the Carotid Plaque Risk in Acute Cerebral Infarction Patients Among Chinese Han Population. J Mol Neurosci 70, 1282–1292 (2020). https://doi.org/10.1007/s12031-020-01540-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12031-020-01540-9

Keywords

Navigation