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Homeostasis and regulation of autoreactive B cells

Cellular & Molecular Immunology volume 17, pages 561–569 (2020)Cite this article

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Abstract

In contrast to the previous belief that autoreactive B cells are eliminated from the normal repertoire of B cells, many autoreactive B cells actually escape clonal deletion and develop into mature B cells. These autoreactive B cells in healthy individuals perform some beneficial functions in the host and are homeostatically regulated by regulatory T and B cells or other mechanisms to prevent autoimmune diseases. Autoreactive B-1 cells constitutively produce polyreactive natural antibodies for tissue homeostasis. Recently, autoreactive follicular B cells were reported to participate actively in the germinal center reaction. Furthermore, the selection and usefulness of autoreactive marginal zone (MZ) B cells found in autoimmune diseases are not well understood, although the repertoire of MZ B-cell receptors (BCRs) is presumed to be biased to detect bacterial antigens. In this review, we discuss the autoreactive B-cell populations among all three major B-cell subsets and their regulation in immune responses and diseases.

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Acknowledgements

This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. NRF-2019R1A2C2006717).

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  1. Department of Immunology, Sungkyunkwan University School of Medicine, Suwon, 16419, Republic of Korea

    Sujin Lee, Yeunjung Ko & Tae Jin Kim

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Lee, S., Ko, Y. & Kim, T.J. Homeostasis and regulation of autoreactive B cells. Cell Mol Immunol 17, 561–569 (2020). https://doi.org/10.1038/s41423-020-0445-4

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