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Changes in Transcriptional Regulation of Postnatal Morphogenesis of the Adrenal Zona Fasciculata Caused by Endocrine Disruptor Dichlorodiphenyltrichloroethane

  • MORPHOLOGY AND PATHOMORPHOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the expression of transcriptional factors regulating postnatal morphogenesis of the adrenal zona fasciculata in rats after developmental exposure to endocrine disruptor DDT. It was found that tissue reparation after trophic disorders and cell death triggered by prenatal and postnatal exposure to DDT was accompanied by an increase in the number of Oct4- and Shh-expressing cells forming a pool located outside the regeneration zones and involved in the maintenance of tissue homeostasis in the zona fasciculata. DDT exposure also disrupted the expression of antiproliferative factor Hhex. The data showed that proliferation of fasciculata cells after termination of adrenal cortex growth was downregulated by inhibition of the expression of Oct4 and Shh and suppression of canonical Wnt signaling, i.e. due to a decrease in the reserve cell pool essential for physiological regeneration, which can reduce the reactive potential of the zona fasciculata.

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Authors and Affiliations

  1. Laboratory of Endocrine System Development, Research Institute of Human Morphology, Moscow, Russia

    N. V. Yaglova, S. S. Obernikhin, S. V. Nazimova & V. V. Yaglov

  2. Laboratory of Biochemistry of Nitrogen Fixation and Nitrogen Metabolism, A. N. Bach Institute of Biochemistry, Federal Research Center of Fundamentals of Biotechnology, Russian Academy of Sciences, Moscow, Russia

    O. V. Kosmachevskaya & A. F. Topunov

Authors
  1. N. V. Yaglova
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  2. S. S. Obernikhin
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  3. S. V. Nazimova
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  4. V. V. Yaglov
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  5. O. V. Kosmachevskaya
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  6. A. F. Topunov
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Corresponding author

Correspondence to N. V. Yaglova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 12, pp. 761-766, December, 2019

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Yaglova, N.V., Obernikhin, S.S., Nazimova, S.V. et al. Changes in Transcriptional Regulation of Postnatal Morphogenesis of the Adrenal Zona Fasciculata Caused by Endocrine Disruptor Dichlorodiphenyltrichloroethane. Bull Exp Biol Med 168, 797–801 (2020). https://doi.org/10.1007/s10517-020-04805-w

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  • DOI: https://doi.org/10.1007/s10517-020-04805-w

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