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Distribution of Ferrihydrite Nanoparticles in the Body and Possibility of Controlling Them in an Isolated Organ by a Permanent Magnetic Field

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We studied the distribution of ferrihydrite nanoparticles isolated from bacteria Klebsiella oxytoca in the whole body in vivo and in a cultured isolated organ (liver). The possibility of controlling these nanoparticles in the body using a magnetic field was assessed. One hour after intravenous injection of ferrihydrite nanoparticles to mice, their accumulation was observed in the liver, lungs, and kidneys. Experiment with cultured isolated rat liver showed that these nanoparticles can be controlled by a magnetic field and the influence of magnetic nanoparticles on the liver over 1 h does not lead to destruction of liver cells associated with the release of the marker enzyme AST. These results show the possibility of using magnetic nanoparticles as a system for controlled drug delivery in the body.

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Authors and Affiliations

  1. Federal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia

    E. V. Inzhevatkin, E. D. Osipova, K. V. Shadrin, V. G. Pakhomova, A. P. Rupenko, N. G. Maksimov, V. P. Ladygina, R. N. Yaroslavtsev & S. V. Stolyar

  2. Siberian Federal University, Krasnoyarsk, Russia

    R. N. Yaroslavtsev & S. V. Stolyar

Authors
  1. E. V. Inzhevatkin
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  2. E. D. Osipova
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  3. K. V. Shadrin
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  4. V. G. Pakhomova
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  5. A. P. Rupenko
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  6. N. G. Maksimov
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  7. V. P. Ladygina
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  8. R. N. Yaroslavtsev
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  9. S. V. Stolyar
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Corresponding author

Correspondence to E. V. Inzhevatkin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 12, pp. 753-756, December, 2019

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Inzhevatkin, E.V., Osipova, E.D., Shadrin, K.V. et al. Distribution of Ferrihydrite Nanoparticles in the Body and Possibility of Controlling Them in an Isolated Organ by a Permanent Magnetic Field. Bull Exp Biol Med 168, 789–792 (2020). https://doi.org/10.1007/s10517-020-04803-y

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  • DOI: https://doi.org/10.1007/s10517-020-04803-y

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