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Analysis of the Pharmacokinetics of Suppository Forms of Bacteriophages

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Pharmacokinetics of suppository forms of bacteriophages was studied on male Chinchilla rabbits. Suppositories with various composition of bacteriophages were administered once per rectum to rabbits, and the presence of phage particles was estimated in the blood, urine, and feces over 24 h. Pharmacokinetic study showed that the phages were detected in the blood, urine, and feces at various terms of the experiment irrespective of the size of viral particles, which confirmed the possibility of their systemic effects after rectal administration. Thus, the use of suppository form of bacteriophages can ensure the presence of phage particles even in infection foci that cannot directly contact with the preparation.

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Authors and Affiliations

  1. G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, The Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia

    S. S. Bochkareva, A. V. Karaulov, A. V. Aleshkin, L. I. Novikova, I. A. Kiseleva, E. O. Rubal’skii, E. R. Mekhtiev, A. O. Styshnev, E. R. Zul’karneev & M. N. Anurova

  2. I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

    A. V. Karaulov, M. N. Anurova & E. O. Bakhrushina

  3. Federal Research Center Fundamentals of Biotechnologies, Russian Academy of Sciences, Moscow, Russia

    A. V. Letarov

Authors
  1. S. S. Bochkareva
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  2. A. V. Karaulov
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  3. A. V. Aleshkin
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  4. L. I. Novikova
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  5. I. A. Kiseleva
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  6. E. O. Rubal’skii
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  7. E. R. Mekhtiev
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  8. A. O. Styshnev
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  9. E. R. Zul’karneev
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  10. M. N. Anurova
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  11. E. O. Bakhrushina
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  12. A. V. Letarov
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Corresponding author

Correspondence to A. V. Aleshkin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 12, pp. 707-711, December, 2019

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Bochkareva, S.S., Karaulov, A.V., Aleshkin, A.V. et al. Analysis of the Pharmacokinetics of Suppository Forms of Bacteriophages. Bull Exp Biol Med 168, 748–752 (2020). https://doi.org/10.1007/s10517-020-04794-w

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  • DOI: https://doi.org/10.1007/s10517-020-04794-w

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