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Beta-Catenin in Non-Small Cells Lung Cancer and Its Association with Proteasomes

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We analyzed the content of β-catenin fractions and activity and content of proteasomes in the tissues of patients with non-small cells lung cancer. The content of β-catenin fractions was elevated and proteasome-dependent proteolysis in the tumor tissue was enhanced in comparison with the corresponding unchanged lung tissue. A negative regression relationship of caspase-like activity of proteasomes and a positive correlation between the content of proteasomes and both fractions of β-catenin were found. We hypothesize that proteasomes are involved in the degradation of β-catenin due to caspase-like activity.

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Authors and Affiliations

  1. Russian Academy of Sciences, Tomsk National Research Medical Center, Tomsk, Russia

    E. S. Kolegova, E. E. Shashova, A. Yu. Dobrodeev & I. V. Kondakova

  2. Tomsk Regional Oncology Center, Tomsk, Russia

    D. N. Kostromitskii

Authors
  1. E. S. Kolegova
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  2. E. E. Shashova
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  3. D. N. Kostromitskii
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  4. A. Yu. Dobrodeev
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  5. I. V. Kondakova
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Corresponding author

Correspondence to E. S. Kolegova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 11, pp. 624-628, November, 2019

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Kolegova, E.S., Shashova, E.E., Kostromitskii, D.N. et al. Beta-Catenin in Non-Small Cells Lung Cancer and Its Association with Proteasomes. Bull Exp Biol Med 168, 677–680 (2020). https://doi.org/10.1007/s10517-020-04779-9

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  • DOI: https://doi.org/10.1007/s10517-020-04779-9

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