Chem
ReviewNickel-Catalyzed C−H Functionalization Using A Non-directed Strategy
The Bigger Picture
The formation of C–C bonds via C–H bond activation has great significance in the field of organic synthesis because it provides an ideal route to the production of valuable chemical compounds. The overall reaction reduces the number of synthetic steps and minimizes by-product formation, thus rendering C–H functionalization environmentally benign and economically attractive. Direct C–H functionalization strategies can facilitate and expedite the synthesis of naturally occurring compounds, biologically active compounds, agriculturally important products, pharmaceutical drug molecules, as well as functional materials. Although various transition-metal complexes can be used as catalysts, nickel-catalyzed C–H activation has become a predominant and ubiquitous research area in organic chemistry because nickel is an abundant, inexpensive metal with unique catalytic activity.