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Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study

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Abstract

Asthma is a serious health problem that involves not only the respiratory system but also the central nervous system. Previous studies identified either regional or network alterations in patients with asthma, but inconsistent results were obtained. A key question remains unclear: are the regional and neural network deficits related or are they two independent characteristics in asthma? Answering this question is the aim of this study. By collecting resting-state functional magnetic resonance imaging from 39 patients with asthma and 40 matched health controls, brain functional measures including regional activity (amplitude of low-frequency fluctuations) and neural network function (degree centrality (DC) and functional connectivity) were calculated to systematically characterize the functional alterations. Patients exhibited regional abnormities in the left angular gyrus, right precuneus, and inferior temporal gyrus within the default mode network. Network abnormalities involved both the sensorimotor network and visual network with key regions including the superior frontal gyrus and occipital lobes. Altered DC in the lingual gyrus was correlated with the degree of airway obstruction. This study elucidated different patterns of regional and network changes, thereby suggesting that the two parameters reflect different brain characteristics of asthma. These findings provide evidence for further understanding the potential cerebral alterations in the pathophysiology of asthma.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (Nos. 81671664 and 81621003), National Program for Support of Top-notch Young Professionals (No. W02070140), Fundamental Research Funds for the Central Universities (No. 2018SCUH0011), Science and Technology Project of the Health Commission of Sichuan Province (No. 18ZD035), Sichuan Science and Technology Program (No. 2019YJ0155), and 1-3-5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (Nos. ZYYC08001 and ZYJC18020).

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  1. These authors contributed equally to this study.

Authors and Affiliations

  1. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041, China

    Siyi Li, Wenjing Zhang, Qiyong Gong & Su Lui

  2. Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, 610041, China

    Peilin Lv

  3. Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China

    Min He, Ting Wang & Yulin Ji

  4. Department of Radiology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610041, China

    Jieke Liu

  5. Department of Geriatric Psychiatry, The Fourth People’s Hospital of Chengdu, Chengdu, 610036, China

    Yao Gong

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  1. Siyi Li
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  2. Peilin Lv
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  3. Min He
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Correspondence to Yulin Ji or Su Lui.

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Siyi Li, Peilin Lv, Min He, Wenjing Zhang, Jieke Liu, Yao Gong, Ting Wang, Qiyong Gong, Yulin Ji, and Su Lui declare that they have no conflict of interest. This study was approved by the Ethical Committee of West China Hospital of Sichuan University, and all procedures followed were in accordance with the ethical standards.

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Li, S., Lv, P., He, M. et al. Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study. Front. Med. 14, 792–801 (2020). https://doi.org/10.1007/s11684-020-0745-1

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