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Senotherapeutics and HIV-1 Persistence

  • HIV Pathogenesis and Treatment (AL Landay and NS Utay, Section Editors)
  • Published:
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Abstract

Purpose of Review

To review the potential use of senotherapeutics, pharmacologic agents that target senescent cells, in addressing HIV-1 persistence.

Recent Findings

Treated HIV-1 infection results in a state of immune exhaustion, which may involve reprogramming of infected and bystander cells toward a state of cellular senescence. Aging research has recently uncovered pathways that make senescent cells uniquely susceptible to pharmacologic intervention. Specific compounds, known as senotherapeutics, have been identified that interrupt pathways senescent cells depend on for survival. Several of these pathways are important in modulating the cellular microenvironment in chronically and latently infected cells. Strategies targeting these pathways may prove useful in combating both HIV-1 persistence and HIV-1-associated immune exhaustion.

Summary

Senotherapeutics have recently been described as potential therapeutics for aging-associated diseases driven by senescent cells. Recently, correlations have emerged between HIV-1 infection, senescence, lifelong chronic infection, and viral persistence. New insights and therapies targeting cellular senescence may offer a novel strategy to address both HIV-1 persistence and immune exhaustion induced by chronic viral infection.

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Funding

This work was supported in part by funding from the National Institutes of Health National Institute on Aging R03AG060192 (AMS) and the Infectious Diseases Society of America 2019 Grants for Emerging Researchers/Clinicians Mentorship (IDSA GERM; MAS).

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  1. Division of Infectious Diseases, Department of Medicine, University of Utah School of Medicine, 30 North 1900 East, Room 4B319, Salt Lake City, UT, 84132, USA

    Matthew A. Szaniawski & Adam M. Spivak

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  1. Matthew A. Szaniawski
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Correspondence to Adam M. Spivak.

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Szaniawski, M.A., Spivak, A.M. Senotherapeutics and HIV-1 Persistence. Curr HIV/AIDS Rep 17, 219–225 (2020). https://doi.org/10.1007/s11904-020-00496-0

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