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A new correction for controlling family-wise error rate in multiple comparison studies

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Abstract

Misleading conclusions can be drawn from multiple comparison studies if the critical p value is set as equivalent to the preselected statistical α level. This incorrect assumption is observed in many research publications where not enough attention was paid to the inflation of the critical p value as a result of increasing the number of comparisons. A new approach is proposed to control the false discovery rate for independent comparisons. The new approach renders more reliable critical p values and allows reducing the inflated values to the original preselected α level.

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References

  1. Araujo P, Frøyland L (2007) Statistical power and analytical quantification. J Chromatogr B 847:305–308

    Article  CAS  Google Scholar 

  2. Bonferroni CE (1936) Teoria statistica delle classi e calcolo delle probabilitá. Reale Istituto Superiore di Scienze Economiche e Commerciali di Firenze, Florence

    Google Scholar 

  3. Šidàk Z (1967) Rectangular confidence region for the means of multivariate normal distributions. J Am Stat Assoc 62:626–633

    Google Scholar 

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Correspondence to Pedro Araujo.

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Araujo, P. A new correction for controlling family-wise error rate in multiple comparison studies. Accred Qual Assur 25, 167–169 (2020). https://doi.org/10.1007/s00769-019-01419-2

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