Skip to main content
SpringerLink
Log in

Anti-inflammatory Effects of Sargachromanol I, Sargachromanol G, and Saringosterol from Hexane Fraction of Myagropsis myagroides

  • Research Paper
  • Biomedical Engineering
  • Published:
Biotechnology and Bioprocess Engineering Aims and scope Submit manuscript

Abstract

The anti-inflammatory activity of benzopyran derivatives extracted from the Myagropsis myagroides against lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophage cell line was examined. The three constituents of M. myagroides extracts were identified as the sargachromanol G, sargachromanol I, and saringosterol by 1H and 13C NMR. Sargachromanol G, sargachromanol I, and saringosterol at concentrations of 50 μg/mL showed inhibitory effects on LPS induced interleukin-6 production (by 84%, 90%, and 96%, respectively) and tumor necrosis factor (by 74%, 82%, and 98%, respectively). These results confirm the potential anti-inflammatory effects of sarga-chromanol G, sargachromanol I, and saringosterol.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Senthilkumar, K. and S. K. Kim (2013) Marine invertebrate natural products for anti-inflammatory and chronic diseases. Evid. Based Complement Alternat. Med. 2013: 572859.

    Article  Google Scholar 

  2. Jeong, D. H., K. B. W. R. Kim, M. J. Kim, B. K. Kang, and D. H. Ahn (2014) Anti-inflammatory activity of methanol extract and n-hexane fraction mojabanchromanol b from Myagropsis myagroides. Life Sci. 114: 12–19.

    Article  CAS  Google Scholar 

  3. Wong, C. K., V. E. C. Ooi, and P. O. Ang Jr. (2004) Hepatoprotective effect of seaweeds’ methanol extract against carbon tetrachloride-induced poisoning in rats. Hydrobiologia. 512: 267–270.

    Article  Google Scholar 

  4. Joung, E. J., M. S. Lee, J. W. Choi, J. S. Kim, T. Shin, B. M. Jung, N. Y. Yoon, C. W. Lim, J. I. Kim, and H. R. Kim (2012) Anti-inflammatory effect of ethanolic extract from Myagropsis myagroides on murine macrophages and mouse ear edema. BMC Complement. Altern. Med. 12: 171.

    Article  Google Scholar 

  5. Lee, S. Y., E. J. Song, K. B. W. R. Kim, S. I. Lim, Y. K. Hong, and D. H. Ahn (2011) Antimicrobial activity of Myagropsis myagroides and interaction with food composition. Food Sci. Biotechnol. 20: 85–92.

    Article  Google Scholar 

  6. Kim, K. B. W. R., B. K. Kang, N. K. Ahn, Y. U. Choi, N. Y. Bae, J. H. Park, S. H. Park, M. J. Kim, and D. H. Ahn (2015) Inhibitory effects of Myagropsis myagroides ethanol extract on 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice. J. Korean Soc. Food Sci. Nutr. 44: 1121–1127.

    Article  Google Scholar 

  7. Cha, S. H., G. N. Ahn, S. J. Heo, K. N. Kim, K. W. Lee, C. B. Song, S. K. Cho, and Y. J. Jeon (2006) Screening of extracts from marine green and brown algae in Jeju for potential marine angiotensin-I converting enzyme (ACE) inhibitory activity. J. Korean Soc. Food Sci. Nutr. 35: 307–314.

    Article  Google Scholar 

  8. Athukorala, Y., K. W. Lee, S. K. Kim, and Y. J. Jeon (2007) Anticoagulant activity of marine green and brown algae collected from Jeju Island in Korea. Bioresour. Technol. 98: 1711–1716.

    Article  CAS  Google Scholar 

  9. Joung, E. J., M. S. Lee, J. W. Choi, J. S. Kim. T. Shin, B. M. Jung, J. I. Kim, and H. R. Kim (2012) Anti-inflammatory effects of phlorofucofuroeckol B-rich ethyl acetate fraction obtained from Myagropsis myagroides on lipopolysaccharide-stimulated RAW 264.7 cells and mouse edema. Int. Immunopharmacol. 14: 471–480.

    Article  CAS  Google Scholar 

  10. Heo, S. J., W. J. Yoon, K. N. Kim, G. N. Ahn, S. M. Kang, D. H. Kang, A. Affan, C. Oh, W. K. Jung, and Y. J. Jeon (2010) Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages. Food Chem. Toxicol. 48: 2045–2051.

    Article  CAS  Google Scholar 

  11. Jang, K. H., B. H. Lee, B. W. Choi, H. S. Lee, and J. Shin (2005) Chromenes from the brown alga Sargassum siliquastrum. J. Nat. Prod. 68: 716–723.

    Article  CAS  Google Scholar 

  12. Heo, S. J., J. Jang, B. R. Ye, M. S. Kim, W. J. Yoon, C. Oh, D. H. Kang, J. H. Lee, M. C. Kang, Y. J. Jeon, S. M. Kang, D. Kim, and K. N. Kim (2014) Chromene suppresses the activation of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 cells. Food Chem. Toxicol. 67: 169–175.

    Article  CAS  Google Scholar 

  13. Kim, S., M. S. Lee, B. Lee, W. G. Gwon, E. J. Joung, N. Y. Yoon, and H. R. Kim (2014) Anti-inflammatory effects of sargachromenol-rich ethanolic extract of Myagropsis myagroides on lipopolysaccharide-stimulated BV-2 cells. BMC Complement. Altern. Med. 14: 231.

    Article  Google Scholar 

  14. Luo, X., P. Su, and W. Zhang (2015) Advances in microalgae-derived phytosterols for functional food and pharmaceutical applications. Mar Drugs. 13: 4231–4254.

    Article  CAS  Google Scholar 

  15. Wächter, G. A., S. G. Franzblau, G. Montenegro, J. J. Hoffmann, W. M. Maiese, and B. N. Timmermann (2001) Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens. J. Nat. Prod. 64: 1463–1464.

    Article  Google Scholar 

  16. Chen, Z., J. Liu, Z. Fu, C. Ye, R. Zhang, Y. Song, Y. Zhang, H. Li, H. Ying, and H. Liu (2014) 24(S)-Saringosterol from edible marine seaweed Sargassum fusiforme is a novel selective LXRβ agonist. J. Agric. Food Chem. 62: 6130–6137.

    Article  CAS  Google Scholar 

  17. Pak, W. M., K. B. W. R. Kim, M. J. Kim, J. Y. Cho, and D. H. Ahn (2015) Inhibitory effect of hexane fraction from Myagropsis myagroides on pancreatic α-amylase in vitro. J. Microbiol. Biotechnol. 25: 328–333.

    Article  CAS  Google Scholar 

  18. Yoon, W. J., J. Y. Moon, G. Song, Y. K. Lee, M. S. Han, J. S. Lee, B. S. Ihm, W. J. Lee, N. H. Lee, and C. G. Hyun (2010) Artemisia fukudo essential oil attenuates LPS-induced inflammation by suppressing NF-kappaB and MAPK activation in RAW 264.7 macrophages. Food Chem. Toxicol. 48: 1222–1229.

    Article  CAS  Google Scholar 

  19. Kofler, S., T. Nickel, and M. Weis (2005) Role of cytokines in cardiovascular diseases: a focus on endothelial responses to inflammation. Clin. Sci. 108: 205–213.

    Article  CAS  Google Scholar 

  20. Ding, C., F. Cicuttini, J. Li, and G. Jones (2009) Targeting IL-6 in the treatment of inflammatory and autoimmune diseases. Expert Opin. Investing. Drugs. 18: 1457–1466.

    Article  CAS  Google Scholar 

  21. Chojnacka, K., A. Saeid, Z. Witkowska, and L. Tuhy (2012) Biologically active compounds in seaweed extracts — the prospects for the application. Open Conf Proc J. 3: 20–28.

    Article  Google Scholar 

  22. Lee, J. H., J. Y. Ko, K. Samarakoon, J. Y. Oh, S. J. Heo, C. Y. Kim, J. W. Nah, M. K. Jang, J. S. Lee, and Y. J. Jeon (2013) Preparative isolation of sargachromanol E from Sargassum siliquastrum by centrifugal partition chromatography and its anti-inflammatory activity. Food Chem Toxicol. 62: 54–60.

    Article  CAS  Google Scholar 

  23. Akihisa, T., Y. Nakamura, M. Tagata, H. Tokuda, K. Yasukawa, E. Uchiyama, T. Suzuki, and Y. Kimura (2007) Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus ganoderma lucidum. Chem. Biodivers. 4: 224–231.

    Article  CAS  Google Scholar 

  24. Kim, K. B. W. R, M. J. Kim, S. M. Jeong, and D. H. Ahn (2019) Free radical scavenging activity and anticollagenase properties of sargachromanol I from Myagropsis myagroides. Indian J. Pharm. Sci. 81: 561–565.

    Google Scholar 

  25. Yoon, W. J., S. J. Heo, S. C. Han, H. J. Lee, G. J. Kang, H. K. Kang, J. W. Hyun, Y. S. Koh, and E. S. Yoo (2012) Anti-inflammatory effect of sargachromanol G isolated from Sargassum siliquastrum in RAW 264.7 cells. Arch. Pharm. Res. 35: 1421–1430.

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2012R1A6A1028677).

The authors declare no conflict of interest.

Neither ethical approval nor informed consent was required for this study.

Author information

Authors and Affiliations

  1. Institute of Fisheries Sciences, Pukyong National University, Busan, 46041, Korea

    Koth-Bong-Woo-Ri Kim & So-Mi Jeong

  2. Department of Food Science & Technology/Institute of Food Science, Pukyong National University, Busan, 48513, Korea

    Da-Hyun Jeong, Min-Ji Kim & Dong-Hyun Ahn

Authors
  1. Koth-Bong-Woo-Ri Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. So-Mi Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Da-Hyun Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Min-Ji Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dong-Hyun Ahn
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dong-Hyun Ahn.

Additional information

Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kim, KBWR., Jeong, SM., Jeong, DH. et al. Anti-inflammatory Effects of Sargachromanol I, Sargachromanol G, and Saringosterol from Hexane Fraction of Myagropsis myagroides. Biotechnol Bioproc E 25, 16–21 (2020). https://doi.org/10.1007/s12257-019-0277-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12257-019-0277-1

Keywords

Search

Navigation