Abstract
Metformin, a potent AMPK activator is the most commonly used drug for diabetes. According to recent reports, metformin lowers the risk of diabetic complications and inflammatory diseases. We found the expression levels of AMPK subunits including PRKAA1, PRKAA2, PRKAB1 and PRKAB2 are decreased in skin biopsies of dermatitis patients from multiple datasets. Interestingly, metformin treatment ameliorates dermatitis symptom in animal model of dermatitis using O-tetradecanoylphorbol-13-acetate (TPA). Especially, the levels of epidermis and dermis thickness were decreased by metformin. We found NFκB activity as well as of gene expression associated with collagen synthesis are attenuated by metformin treatment. These results suggest that metformin treatment alleviates animal model of dermatitis.
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Data availability
All study data are available from the corresponding author upon request.
Abbreviations
- AMPK:
-
AMP-activated protein kinase
- TPA:
-
O-Tetradecanoylphorbol-13-acetate
- NFкB:
-
Nuclear Factor kappa B
- IFN:
-
Interferon
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Acknowledgements
We thank Na kyung Jeong for assisting histological analysis.
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This work is supported by the GeneCellPharm Corporation (Grant no. I101).
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SYC, MJH, CML, YMC and JHJ designed the experiments and analyzed the data. MJH, SYC and CML performed the experiments. SB, JHJ and SA wrote the manuscript. ISA supported research grant.
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All animals were care for using protocols approved by the Institutional Animal Care and Use Committee (Konkuk University, Republic of Korea). No. KU10160. All methods were performed in accordance with the relevant guidelines and regulations.
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Choi, S.Y., Lee, C., Heo, MJ. et al. Metformin ameliorates animal models of dermatitis. Inflammopharmacol 28, 1293–1300 (2020). https://doi.org/10.1007/s10787-020-00704-8
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DOI: https://doi.org/10.1007/s10787-020-00704-8