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Seroprevalence of Trypanosoma cruzi Infection in Pregnant Women Suggests a High Risk for Congenital Transmission in Central Veracruz, Mexico

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Abstract

Purpose

The state of Veracruz, Mexico, is a well-recognized endemic region for Chagas disease, but congenital transmission has not been extensively studied. We estimated here the prevalence and the risk of congenital transmission of Trypanosoma cruzi in pregnant women from 27 municipalities of central Veracruz.

Methods

528 sera from pregnant women were analyzed by ELISA and IFA assays for the detection of IgG antibodies against T. cruzi.

Results

The presence of anti-T. cruzi antibodies was identified in women from 17 municipalities, obtaining an overall seroprevalence of 17.0%. A higher seropositivity was observed in the municipalities of Orizaba (25.2%), Nogales (13.6%), and Río Blanco (10.5%). The results suggest that there is a high risk of congenital transmission of T. cruzi in the region.

Conclusion

There are currently limited actions for the surveillance and control of congenital transmission of Chagas disease in Veracruz.

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Acknowledgements

The authors appreciate the support provided by the department of gynecology and obstetrics of the “Rio Blanco” Hospital for obtaining samples.

Funding

RSGC was recipient of a Ph.D. fellowship from CONACyT, Mexico (No. 286884). This work was supported by grant FOMIX CONACyT-Gobierno del Estado de Veracruz (VER-2008-C02-108783).

Author information

Authors and Affiliations

  1. LADISER Inmunología y Biología Molecular, Facultad de Ciencias Químicas, Universidad Veracruzana, Prolongación Oriente 6, No. 1009, Col. Rafael Alvarado, Orizaba, Mexico

    Aracely López-Monteon, Ruth Sarahi González-Constantino & Angel Ramos-Ligonio

  2. Instituto de Salud Pública, Universidad Veracruzana, Av. Luis Castelazo Ayala, s/n., Col. Industrial Ánimas, 91190, Xalapa, Veracruz, Mexico

    Hilda Montero

  3. Maestria en Procesos Biológicos, Universidad Veracruzana, Prolongación Oriente 6, No.1009, Col. Rafael Alvarado, 94340, Orizaba, Veracruz, Mexico

    Ruth Sarahi González-Constantino

  4. Facultad de Medicina y Hospital Universitario, Servicio de Inmunología, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico

    Alberto Yair Limón-Flores

  5. Facultad de Medicina, Universidad Veracruzana, Hidalgo y Carrillo s/n, Camerino Z., 94740, Mendoza, Veracruz, Mexico

    Miguel Varela-Cardoso & Gerardo Luna-Hernández

  6. Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA

    Eric Dumonteil

Authors
  1. Aracely López-Monteon
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  2. Hilda Montero
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  3. Ruth Sarahi González-Constantino
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  4. Alberto Yair Limón-Flores
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  5. Miguel Varela-Cardoso
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  6. Gerardo Luna-Hernández
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  7. Eric Dumonteil
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  8. Angel Ramos-Ligonio
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Corresponding author

Correspondence to Angel Ramos-Ligonio.

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López-Monteon, A., Montero, H., González-Constantino, R.S. et al. Seroprevalence of Trypanosoma cruzi Infection in Pregnant Women Suggests a High Risk for Congenital Transmission in Central Veracruz, Mexico. Acta Parasit. 65, 661–668 (2020). https://doi.org/10.2478/s11686-020-00197-z

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  • DOI: https://doi.org/10.2478/s11686-020-00197-z

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