Abstract
As a member of the kinesin-3 family, kinesin family member 16B (KIF16B) has a characteristic PhoX homology (PX) domain that binds to membranes containing phosphatidylinositol-3-phosphate (PI(3)P) and moves along microtubule filaments to the plus end via a process regulated by coiled coils in the stalk region in various cell types. The physiological function of KIF16B supports the transport of intracellular cargo and the formation of endosomal tubules. Ras-related protein (Rab) coordinates many steps of membrane transport and are involved in the regulation of KIF16B-mediated vesicle trafficking. Data obtained from clinical research suggest that KIF16B has a potential effect on the disease processes in intellectual disability, abnormal lipid metabolism, and tumor brain metastasis. In this review, we summarize recent advances in the structural and physiological characteristics of KIF16B as well as diseases associated with KIF16B disorders, and speculating its role as a potential adaptor for intracellular cholesterol trafficking.
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Abbreviations
- CC:
-
Coiled coil
- EGFR:
-
Epidermal growth factor receptor
- FGFR:
-
Fibroblast growth factor receptor
- KIF16B:
-
Kinesin family member 16B
- NC:
-
Neck coil
- PA:
-
Phosphatidic acid
- PI(3)P:
-
Phosphatidylinositol-3-phosphate
- PTPD1:
-
Protein tyrosine phosphatase 1
- PX:
-
PhoX homology
- Rab:
-
Ras-related protein
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Acknowledgements
This study was funded by National Nature Science Fund of China (Grant no. 81600291) and Nature Science Fund of Hunan province (Grant No. 2018JJ2348) to Cai-ping Zhang, National Nature Science Fund of China (Grant no. 81673722) to Qin-hui Tuo, Nature Science Fund of Hunan province (Grant no. 2018JJ2346) to Shi-yin Long, Hunan Provincial Innovation Foundation for Postgraduate (Grant no. CX2018B62) to Chu-yao Wang.
Funding
This study was funded by National Nature Science Fund of China (Grant nos. 81600291, 81673722), Nature Science Fund of Hunan province (Grant nos. 2018JJ2348, 2018JJ2346), Hunan Provincial Innovation Foundation for Postgraduate (Grant No. CX2018B62), and the construct program of the Pharmaceutical Science key discipline in Hunan province.
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Li, Bj., Chen, H., Jiang, Ss. et al. PX Domain-Containing Kinesin KIF16B and Microtubule-Dependent Intracellular Movements. J Membrane Biol 253, 101–108 (2020). https://doi.org/10.1007/s00232-020-00110-9
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DOI: https://doi.org/10.1007/s00232-020-00110-9