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Transcatheter Mitral Valve Replacement: State of the Art

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Abstract

The emergence of transcatheter aortic valve replacement (TAVR) has segued the development of transcatheter mitral valve (MV) repair devices. Transcatheter mitral valve repair has become a well-established alternative for patients with severe primary and secondary mitral regurgitation (MR) and with a perceived surgical risk. Transcatheter mitral valve replacement (TMVR) could become a more complete form of reduction of severe MR compared to MV repair devices, albeit with significant engineering challenges and all the risks associated with a bioprosthetic heart valve. The development of TMVR devices has become prominent while companies race to become the first commercially available system. Careful consideration of design challenges should be conducted by the developmental companies to ensure successful devices. Preclinical and clinical trials have shown promising results, showcasing the feasibility of total valve replacement utilizing transcatheter procedure techniques. Further development, testing, and trials need to be conducted before TMVR can become a sensible MR treatment. This review describes design challenges and considerations along with the state of the art, involving designs in both clinical and preclinical stages.

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Acknowledgments

The authors acknowledge the University of British Columbia and NSERC (Discovery Grant), Mitacs Accelerate Program and Angeleno Medical Inc for financial support.

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None declared.

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In partnership with Angeleno Medical Ltd. University of British Columbia and NSERC Discovery Program.

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Authors and Affiliations

  1. The Heart Valve Performance Laboratory, School of Engineering, Faculty of Applied Science, University of British Columbia Okanagan, Kelowna, BC, V1V 1V7, Canada

    Dylan Goode, Ruby Dhaliwal & Hadi Mohammadi

  2. Department of Surgery, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

    Hadi Mohammadi

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Correspondence to Hadi Mohammadi.

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Goode, D., Dhaliwal, R. & Mohammadi, H. Transcatheter Mitral Valve Replacement: State of the Art. Cardiovasc Eng Tech 11, 229–253 (2020). https://doi.org/10.1007/s13239-020-00460-4

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