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Cell-based approaches towards treating age-related macular degeneration

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Abstract

Age-related macular degeneration as one of the most common causes of worldwide vision loss needs a proper approach for treatment. Therein, cell therapy and regenerative medicine can hold a great promise to be an effective approach. Accordingly, some preclinical and clinical studies were conducted to search around the therapeutic influence of stem cells in Age-related macular degeneration models and subjects. Hereupon, the purpose of the current review is to discuss the mechanisms of age-related macular degeneration, appropriate animal models along with suitable dosage and route of stem cell administration for its treatment.

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Abbreviations

AMD:

Age-related macular degeneration

VEGF:

Vascular endothelial growth factor

FDA:

Food and drug administration

BMI:

Body mass index

CCL-2:

Chemoattractant protein-2

CCR-2:

C-C chemokine receptor-2

LIPC:

Hepatic lipase

TIMP-3:

Tissue inhibitor of metalloproeinase-3

IER-3:

Immediate early response-3

ESCs:

Embryonic stem cells

iPSCs:

induced pluripotent stem cells

MSCs:

Mesenchymal stem cells

RPE:

Retinal pigment epithelium

RPC:

Retinal progenitor cell

hESC-RPE:

Human embryonic stem cell derived retinal pigmented epithelial

SMD:

Stargardt’s macular dystrophy

RP:

Retinal pigment

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Acknowledgements

The authors would like to thank Dr. Mohsen Khorshidi and Shokouh Slaimi for their considerable assistance.

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Authors and Affiliations

  1. Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Alireza Baradaran-Rafii

  2. Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Alireza Baradaran-Rafii

  3. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Masoumeh Sarvari, Sepideh Alavi-Moghadam, Hamid Reza Aghayan & Babak Arjmand

  4. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Moloud Payab

  5. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

    Parisa Goodarzi

  6. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Bagher Larijani & Mahmood Biglar

  7. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mostafa Rezaei-Tavirani

  8. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Babak Arjmand

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  1. Alireza Baradaran-Rafii
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  2. Masoumeh Sarvari
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Baradaran-Rafii, A., Sarvari, M., Alavi-Moghadam, S. et al. Cell-based approaches towards treating age-related macular degeneration. Cell Tissue Bank 21, 339–347 (2020). https://doi.org/10.1007/s10561-020-09826-3

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