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Nanoelectrokinetic Selective Preconcentration Based on Ion Concentration Polarization

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Abstract

Nanoscale electrokinetic phenomenon called ion concentration polarization (ICP) has opened a new era in bio- and chemical-analysis platform due to its high efficiency and easy sample handling. In this review, the most recent advancements of selective preconcentration process using ICP were introduced. The flux balances of charged analytes were theoretically analyzed so that the behavior and the shape of preconcentrated plug were categorized into stacking/propagating and dumbbell/plug, respectively. The experimental demonstrations of these features were also given to verify the modeling. Furthermore, promising applications based on the analysis were described in this review. Lastly, future research direction would be suggested by elucidating pros and cons of ICP process.

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Acknowledgements

This work was supported by Basic Research Laboratory Project (NRF-2018R1A 4A1022513) by Ministry of Science and ICT. All authors acknowledge the support from BK21+ program of Creative Research Engineer Development IT, SNU.

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  1. These authors contrilbuted equally.

Authors and Affiliations

  1. Department of Electrical and Computer Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea

    Jihye Choi, Seongho Baek & Sung Jae Kim

  2. Department of Biomedical Engineering, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea

    Hee Chan Kim

  3. Department of Pediatrics, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea

    Jong-Hee Chae

  4. Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea

    Youngil Koh

  5. School of Chemical and Biological Engineering, Institute of Chemical Process, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea

    Sang Woo Seo

  6. Department of Chemical and Biological Engineering, Jeju National University, 102 Jejudaehak-ro, Jeju-si, Jeju, 63243, Republic of Korea

    Hyomin Lee

  7. Nano Systems Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea

    Sung Jae Kim

  8. Inter-university Semiconductor Research Center, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea

    Sung Jae Kim

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  1. Jihye Choi
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Correspondence to Hyomin Lee or Sung Jae Kim.

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Choi, J., Baek, S., Kim, H.C. et al. Nanoelectrokinetic Selective Preconcentration Based on Ion Concentration Polarization. BioChip J 14, 100–109 (2020). https://doi.org/10.1007/s13206-020-4109-3

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